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Accueil Tous les numéros Volume 217 / Numéro 3-4 (2023) Biologie Aujourd’hui, 217 3-4 (2023) 253-263 Références
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Numéro
Biologie Aujourd’hui
Volume 217, Numéro 3-4, 2023
Page(s) 253 - 263
DOI https://doi.org/10.1051/jbio/2023031
Publié en ligne 29 novembre 2023
  • Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W. S. T., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I. R., McGeer, P.L., O’Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Van Muiswinkel, F. L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., Wyss-Coray, T. (2000). Inflammation and Alzheimer’s disease. Neurobiol Aging, 21, 383-421. [CrossRef] [PubMed] [Google Scholar]
  • Alarim, R.A., Alasmre, F.A., Alotaibi, H.A., Alshehri, M.A., Hussain, S.A. (2020). Effects of the Ketogenic Diet on Glycemic Control in Diabetic Patients: Meta-Analysis of Clinical Trials. Cureus, 12, e10796. [PubMed] [Google Scholar]
  • An, Y., Varma, V. R., Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, C. W., Egan, J. M., Ferrucci, L., Troncoso, J., Levey, A. I., Lah, J., Seyfried, N. T., Legido-Quigley, C., O’Brien, R., Thambisetty, M. (2018). Evidence for brain glucose dysregulation in Alzheimer’s disease. Alzheimers Dement, 14, 318-329. [CrossRef] [PubMed] [Google Scholar]
  • Audinat, É., Arnoux, I. (2014). La microglie : des cellules immunitaires qui sculptent et contrôlent les synapses neuronales. Med Sci, 30, 153-159. [Google Scholar]
  • Augustin, K., Khabbush, A., Williams, S., Eaton, S., Orford, M., Cross, J. H., Heales, S.J.R., Walker, M.C., Williams, R.S.B. (2018). Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders. Lancet Neurol, 17, 84-93. [CrossRef] [PubMed] [Google Scholar]
  • Bach, A., Schirardin, H., Weryha, A., Bauer, M. (1977). Ketogenic Response to Medium-Chain Triglyceride Load in the Rat. J Nutr, 107, 1863-1870. [CrossRef] [PubMed] [Google Scholar]
  • Benito, A., Hajji, N., O’Neill, K., Keun, H. C., Syed, N. (2020). β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells. Metabolites, 26, 346. [CrossRef] [PubMed] [Google Scholar]
  • Benoit, M., Staccini, P., Brocker, P., Benhamidat, T., Bertogliati, C., Lechowski, L., Tortrat, D., Robert, P. H. (2003). Symptômes comportementaux et psychologiques dans la maladie d’ Alzheimer : Résultats de l’étude REAL.FR. Rev Med Interne, 24, 319s-324s. [CrossRef] [PubMed] [Google Scholar]
  • Bielohuby, M., Sisley, S., Sandoval, D., Herbach, N., Zengin, A., Fischereder, M., Menhofer, D., Stoehr, B.J.M., Stemmer, K., Wanke, R., Tschöp, M.H., Seeley, R.J., Bidlingmaier, M. (2013). Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab., 305, E1059-E1070. [CrossRef] [PubMed] [Google Scholar]
  • Blazhenets, G., Frings, L., Ma, Y., Sörensen, A., Eidelberg, D., Wiltfang, J., Meyer, P.T., for the Alzheimer’s Disease Neuroimaging Initiative. (2021). Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration. Neurology, 96, e1358-e1368. [CrossRef] [PubMed] [Google Scholar]
  • Brandt, J., Buchholz, A., Henry-Barron, B., Vizthum, D., Avramopoulos, D., Cervenka, M. C. (2019). Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease. J Alzheimers Dis, 68, 969-981. [CrossRef] [PubMed] [Google Scholar]
  • Butterfield, D. A., Halliwell, B. (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci, 20, 148-160. [CrossRef] [PubMed] [Google Scholar]
  • Castro, C.B., Dias, C.B., Hillebrandt, H., Sohrabi, H.R., Chatterjee, P., Shah, T.M., Fuller, S.J., Garg, M.L., Martins, R.N. (2023). Medium-chain fatty acids for the prevention or treatment of Alzheimer’s disease : a systematic review and meta-analysis. Nutr Rev, nuac104. [Google Scholar]
  • Charlot, A., Conrad, O., Zoll, J. (2020). Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ? Biol Aujourdhui, 214, 115-123. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  • Charlot, A., Boumiza, R., Roux, M., Zoll, J. (2021). Obésité, inflammation et COVID-19 : intérêt préventif de l’alimentation cétogène ? Biol Aujourdhui, 215, 63-72. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  • Charlot, A., Morel, L., Bringolf, A., Georg, I., Charles, A.L., Goupilleau, F., Geny, B., Zoll, J. (2022). Octanoic Acid-Enrichment Diet Improves Endurance Capacity and Reprograms Mitochondrial Biogenesis in Skeletal Muscle of Mice. Nutrients, 14, 2721. [CrossRef] [PubMed] [Google Scholar]
  • Charlot, A., Zoll, J. (2022). Beneficial Effects of the Ketogenic Diet in Metabolic Syndrome: A Systematic Review. Diabetology, 3, 292-309. [CrossRef] [Google Scholar]
  • Cheng, Y., Bai, F. (2018). The Association of Tau with Mitochondrial Dysfunction in Alzheimer’s Disease. Front Neurosci, 12, 163. [CrossRef] [PubMed] [Google Scholar]
  • Conti Filho, C.E., Loss, L.B., Marcolongo-Pereira, C., Rossoni Junior, J.V., Barcelos, R.M., Chiarelli-Neto, O., da Silva, B.S., Passamani Ambrosio, R., Castro, F.C.A.Q., Teixeira, S.F., Mezzomo, N.J. (2023). Advances in Alzheimer’s disease’s pharmacological treatment. Front Pharmacol, 26, 14, 1101452. [CrossRef] [PubMed] [Google Scholar]
  • Croteau, E., Castellano, C.-A., Richard, M. A., Fortier, M., Nugent, S., Lepage, M., Duchesne, S., Whittingstall, K., Turcotte, É. E., Bocti, C., Fülöp, T., Cunnane, S. C. (2018). Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease. J Alzheimers Dis, 64, 551-561. [CrossRef] [PubMed] [Google Scholar]
  • De la Rosa, A., Olaso-Gonzalez, G., Arc-Chagnaud, C., Millan, F., Salvador-Pascual, A., García-Lucerga, C., Blasco-Lafarga, C., Garcia-Dominguez, E., Carretero, A., Correas, A.G., Viña, J., Gomez-Cabrera, M. C. (2020). Physical exercise in the prevention and treatment of Alzheimer’s disease. J Sport Health Sci, 9, 394-404. [CrossRef] [PubMed] [Google Scholar]
  • Diniz, B.S., Butters, M.A., Albert, S.M., Dew, M.A., Reynolds, C.F. (2013). Late-life depression and risk of vascular dementia and Alzheimer’s disease: Systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry, 202, 329-335. [CrossRef] [PubMed] [Google Scholar]
  • Drewnowski, A., Shultz, J. M. (2001). Impact of aging on eating behaviors, food choices, nutrition, and health status. J Nutr Health Aging, 5, 75-79. [PubMed] [Google Scholar]
  • Du, H., Guo, L., Yan, S., Sosunov, A.A., McKhann, G.M., Shi Du Yan, S. (2010). Early deficits in synaptic mitochondria in an Alzheimer’s disease mouse model. Proc Natl Acad Sci USA, 107, 18670-18675. [CrossRef] [PubMed] [Google Scholar]
  • Dupuis, N., Curatolo, N., Benoist, J.-F., Auvin, S. (2015). Ketogenic diet exhibits anti-inflammatory properties. Epilepsia, 56, e95-e98. [PubMed] [Google Scholar]
  • Ebanks, B., Ingram, T.L., Chakrabarti, L. (2020). ATP synthase and Alzheimer’s disease: Putting a spin on the mitochondrial hypothesis. Aging (Albany NY), 12, 16647-16662. [CrossRef] [PubMed] [Google Scholar]
  • Ellenbroek, J.H., van Dijck, L., Töns, H.A., Rabelink, T.J., Carlotti, F., Ballieux, B.E.P.B., de Koning, E.J.P. (2014). Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice. Am J Physiol Endocrinol Metab, 306, E552-E558. [CrossRef] [PubMed] [Google Scholar]
  • Fortier, M., Castellano, C.-A., Croteau, E., Langlois, F., Bocti, C., St-Pierre, V., Vandenberghe, C., Bernier, M., Roy, M., Descoteaux, M., Whittingstall, K., Lepage, M., Turcotte, É.E., Fulop, T., Cunnane, S.C. (2019). A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimers Dement, 15, 625-634. [CrossRef] [PubMed] [Google Scholar]
  • Gatz, M., Reynolds, C.A., Fratiglioni, L., Johansson, B., Mortimer, J.A., Berg, S., Fiske, A., Pedersen, N.L. (2006). Role of Genes and Environments for Explaining Alzheimer Disease. Arch Gen Psychiatry, 63, 168. [CrossRef] [PubMed] [Google Scholar]
  • Goldberg, E.L., Asher, J.L., Molony, R.D., Shaw, A.C., Zeiss, C.J., Wang, C., Morozova-Roche, L.A., Herzog, R.I., Iwasaki, A., Dixit, V. D. (2017). β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep, 18, 2077-2087. [CrossRef] [PubMed] [Google Scholar]
  • Gómora-García, J.C., Montiel, T., Hüttenrauch, M., Salcido-Gómez, A., García-Velázquez, L., Ramiro-Cortés, Y., Gomora, J.C., Castro-Obregón, S., Massieu, L. (2023). Effect of the Ketone Body, D-β-Hydroxybutyrate, on Sirtuin2-Mediated Regulation of Mitochondrial Quality Control and the Autophagy-Lysosomal Pathway. Cells, 12, 486. [CrossRef] [PubMed] [Google Scholar]
  • Goss, A.M., Gower, B., Soleymani, T., Stewart, M., Pendergrass, M., Lockhart, M., Krantz, O., Dowla, S., Bush, N., Garr Barry, V., Fontaine, K.R. (2020). Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: A randomized clinical trial. Nutr Metab (Lond), 17, 64. [CrossRef] [PubMed] [Google Scholar]
  • Gough, S.M., Casella, A., Ortega, K.J., Hackam, A.S. (2021). Neuroprotection by the Ketogenic Diet : Evidence and Controversies. Front Nutr, 8, 782657. [CrossRef] [PubMed] [Google Scholar]
  • Grandl, G., Straub, L., Rudigier, C., Arnold, M., Wueest, S., Konrad, D., Wolfrum, C. (2018). Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet. J Physiol, 596, 4597-4609. [CrossRef] [PubMed] [Google Scholar]
  • Greenwood, C.E., Parrott, M.D. (2017). Nutrition as a component of dementia risk reduction strategies. Health Manage Forum, 30, 40-45. [CrossRef] [PubMed] [Google Scholar]
  • Haces, M.L., Hernández-Fonseca, K., Medina-Campos, O.N., Montiel, T., Pedraza-Chaverri, J., Massieu, L. (2008). Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions. Exp Neurol, 211, 85-96. [CrossRef] [PubMed] [Google Scholar]
  • Harvey, C.C.J., Schofield, G.M., Williden, M., McQuillan, J.A. (2018). The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial. J Nutr Metab, 2018, 2630565. [CrossRef] [Google Scholar]
  • Hasan-Olive, M.M., Lauritzen, K.H., Ali, M., Rasmussen, L.J., Storm-Mathisen, J.,Bergersen, L.H. (2019). A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis. Neurochem Res, 44, 22-37. [CrossRef] [PubMed] [Google Scholar]
  • Haute Autorité de Santé [Internet]. (2007). Stratégie de prise en charge en cas de dénutrition protéino-énergétique chez la personne âgée. Haute Autorité de Santé. Disponible sur : https://www.has-sante.fr/jcms/c_546549/fr/strategie-de-prise-en-charge-en-cas-de-denutrition-proteino-energetique-chez-la-personne-agee. [Google Scholar]
  • Heneka, M.T., Carson, M.J., El Khoury, J., Landreth, G.E., Brosseron, F., Feinstein, D.L., Jacobs, A.H., Wyss-Coray, T., Vitorica, J., Ransohoff, R.M., Herrup, K., Frautschy, S.A., Finsen, B., Brown, G.C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., Petzold, G.C., Town, T., Morgan, D., Shinohara, M.L., Perry, V.H., Holmes, C., Bazan, N.G., Brooks, D.J., Hunot, S., Joseph, B., Deigendesch, N., Garaschuk, O., Boddeke, E., Dinarello, C.A., Breitner, J.C., Cole, G.M., Golenbock, D.T., Kummer, M.P. (2015). Neuroinflammation in Alzheimer’s Disease. Lancet Neurol, 14, 388-405. [CrossRef] [PubMed] [Google Scholar]
  • Herholz, K. (2010). Cerebral glucose metabolism in preclinical and prodromal Alzheimer’s disease. Expert Rev Neurother, 10, 1667-1673. [CrossRef] [PubMed] [Google Scholar]
  • Hersant, H., Grossberg, G. (2022). The Ketogenic Diet and Alzheimer’s Disease. J Nutr Health Aging, 26, 606–614. [CrossRef] [PubMed] [Google Scholar]
  • Hou, Y., Moreau, F., Chadee, K. (2012). PPARγ is an E3 ligase that induces the degradation of NFκB/p65. Nat Commun, 3, 1300. [CrossRef] [PubMed] [Google Scholar]
  • INSERM [Internet]. (2006). Orphanet : syndrome de déficit en transporteur du glucose de type 1, forme classique. Disponible sur : https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=71277. [Google Scholar]
  • Jack, C.R., Bennett, D.A., Blennow, K., Carrillo, M.C., Dunn, B., Haeberlein, S.B., Holtzman, D.M., Jagust, W., Jessen, F., Karlawish, J., Liu, E., Molinuevo, J.L., Montine, T., Phelps, C., Rankin, K. P., Rowe, C.C., Scheltens, P., Siemers, E., Snyder, H.M., Sperling, R. (2018). NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement, 14, 535-562. [CrossRef] [PubMed] [Google Scholar]
  • Jensen, N. J., Wodschow, H. Z., Nilsson, M., Rungby, J. (2020). Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. Int J Mol Sci, 21, 8767. [CrossRef] [PubMed] [Google Scholar]
  • Koepsell, H. (2020). Glucose transporters in brain in health and disease. Pflügers Arch, 472, 1299-1343. [CrossRef] [PubMed] [Google Scholar]
  • Kondo, K., Kikuta, S., Ueha, R., Suzukawa, K., Yamasoba, T. (2020). Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management. Front Aging Neurosci, 12, 208. [CrossRef] [PubMed] [Google Scholar]
  • Kong, G., Wang, J., Li, R., Huang, Z., Wang, L. (2022). Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther, 24, 113. [CrossRef] [PubMed] [Google Scholar]
  • Krikorian, R., Shidler, M.D., Dangelo, K., Couch, S.C., Benoit, S.C., Clegg, D.J. (2012). Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging, 33, 425.e19-425.e27. [CrossRef] [PubMed] [Google Scholar]
  • Kumar, S., Behl, T., Sachdeva, M., Sehgal, A., Kumari, S., Kumar, A., Kaur, G., Yadav, H.N., Bungau, S. (2021). Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus. Life Sci, 264, 118661. [CrossRef] [PubMed] [Google Scholar]
  • Leibson, C.L., Rocca, W.A., Hanson, V.A., Cha, R., Kokmen, E., O’Brien, P. C., Palumbo, P.J. (1997). Risk of dementia among persons with diabetes mellitus: A population-based cohort study. Am J Epidemiol, 145, 301-308. [CrossRef] [PubMed] [Google Scholar]
  • Lilamand, M., Mouton-Liger, F., Di Valentin, E., Sànchez Ortiz, M., Paquet, C. (2022). Efficacy and Safety of Ketone Supplementation or Ketogenic Diets for Alzheimer’s Disease: A Mini Review. Front Nutr, 8, 807970. [CrossRef] [PubMed] [Google Scholar]
  • Liu, Y. C., Wang, H.-S. (2013). Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets. Biomed J, 36, 9-15. [CrossRef] [PubMed] [Google Scholar]
  • Loughman, A., Staudacher, H. M., Rocks, T., Ruusunen, A., Marx, W., O Apos Neil, A., Jacka, F.N. (2021). Diet and Mental Health. Mod Trends Psychiatry, 32, 100-112. [CrossRef] [PubMed] [Google Scholar]
  • Lyons, L., Schoeler, N.E., Langan, D., Cross, J. H. (2020). Use of ketogenic diet therapy in infants with epilepsy : A systematic review and meta-analysis. Epilepsia, 61, 1261-1281 [CrossRef] [PubMed] [Google Scholar]
  • Majou, D. (2015). Alzheimer’s disease: Origins, mechanisms, people at risk and prevention by DHA (omega-3 fatty acid). Actia Editions. [Google Scholar]
  • Manczak, M., Anekonda, T.S., Henson, E., Park, B.S., Quinn, J., Reddy, P.H. (2006). Mitochondria are a direct site of a beta accumulation in Alzheimer’s disease neurons: Implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet, 15, 1437-1449. [CrossRef] [PubMed] [Google Scholar]
  • Marucci, G., Buccioni, M., Ben, D.D., Lambertucci, C., Volpini, R., Amenta, F. (2021). Efficacy of acetylcholinesterase inhibitors in Alzheimer’s disease. Neuropharmacology, 190, 108352. [CrossRef] [PubMed] [Google Scholar]
  • Mergenthaler, P., Lindauer, U., Dienel, G. A., Meisel, A. (2013). Sugar for the brain: The role of glucose in physiological and pathological brain function. Trends Neurosci, 36, 587-597. [CrossRef] [PubMed] [Google Scholar]
  • Meyer-Rogge, S., Meyer-Rogge, K. (2012). Biochimie métabolique. De Boeck. ISBN 978-2-8041-7147-6 [Google Scholar]
  • Moriconi, E., Camajani, E., Fabbri, A., Lenzi, A., Caprio, M. (2021). Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes. Nutrients, 13, 758. [CrossRef] [PubMed] [Google Scholar]
  • Mosconi, L. (2005). Brain glucose metabolism in the early and specific diagnosis of Alzheimers disease: FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging, 32, 486-510. [CrossRef] [MathSciNet] [PubMed] [Google Scholar]
  • Nakao, R., Abe, T., Yamamoto, S., Oishi, K. (2019). Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice. Sci Rep, 9, 19652. [CrossRef] [PubMed] [Google Scholar]
  • Nishida, Y., Winkler, E., Sagare, A., De Vivo, D., Zlokovic, B. (2017). Decreased glucose transporter 1 expression at the blood-brain barrier exacerbates Alzheimer disease-like phenotypes in mouse models. J Neurol Sci, 381, 768. [CrossRef] [Google Scholar]
  • Norgren, J., Sindi, S., Sandebring-Matton, A., Kåreholt, I., Daniilidou, M., Akenine, U., Nordin, K., Rosenborg, S., Ngandu, T., Kivipelto, M. (2020). Ketosis after Intake of Coconut Oil and Caprylic Acid—With and Without Glucose: A Cross-Over Study in Healthy Older Adults. Front Nutr, 7, 40. [CrossRef] [PubMed] [Google Scholar]
  • Organisation mondiale de la santé [Internet]. (2020). La démence. Organisation mondiale de la santé. Disponible sur : https://www.who.int/fr/news-room/fact-sheets/detail/dementia. [Google Scholar]
  • Ota, M., Matsuo, J., Ishida, I., Takano, H., Yokoi, Y., Hori, H., Yoshida, S., Ashida, K., Nakamura, K., Takahashi, T., Kunugi, H. (2019). Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease. Neurosci Lett, 690, 232-236. [CrossRef] [PubMed] [Google Scholar]
  • Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., Martínez-Lage, P. (2014). Diet, cognition, and Alzheimer’s disease: Food for thought. Eur J Nutr, 53, 1-23. [CrossRef] [Google Scholar]
  • Parker, W. D. (1991). Cytochrome oxidase deficiency in Alzheimer’s disease. Ann N Y Acad Sci, 640, 59-64. [CrossRef] [PubMed] [Google Scholar]
  • Perez Ortiz, J.M., Swerdlow, R.H. (2019). Mitochondrial dysfunction in Alzheimer’s disease: Role in pathogenesis and novel therapeutic opportunities. Br J Pharmacol, 176, 3489-3507. [CrossRef] [PubMed] [Google Scholar]
  • Prasuhn, J., Davis, R.L., Kumar, K.R. (2021). Targeting Mitochondrial Impairment in Parkinson’s Disease : Challenges and Opportunities. Front Cell Dev Biol, 8, 615461. [CrossRef] [PubMed] [Google Scholar]
  • Rahman, M., Muhammad, S., Khan, M.A., Chen, H., Ridder, D.A., Müller-Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., Okun, J. G., Offermanns, S., Schwaninger, M. (2014). The β-hydroxybutyrate receptor HCA 2 activates a neuroprotective subset of macrophages. Nat Commun, 5, 1-11. [CrossRef] [Google Scholar]
  • Rahman, A., Hossen, M.A., Chowdhury, M.F.I., Bari, S., Tamanna, N., Sultana, S.S., Haque, S.N., Al Masud, A., Saif-Ur-Rahman, K.M. (2023). Aducanumab for the treatment of Alzheimer’s disease : a systematic review. Psychogeriatrics, 23, 512-522. [CrossRef] [PubMed] [Google Scholar]
  • Reger, M.A., Henderson, S.T., Hale, C., Cholerton, B., Baker, L.D., Watson, G.S., Hyde, K., Chapman, D., Craft, S. (2004). Effects of β-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging, 25, 311-314. [CrossRef] [PubMed] [Google Scholar]
  • Rojas-Morales, P., Pedraza-Chaverri, J., Tapia, E. (2020) Ketone bodies, stress response, and redox homeostasis. Redox Biol, 29, 101395. [CrossRef] [PubMed] [Google Scholar]
  • Rusek, M., Pluta, R., Ułamek-Kozioł, M., Czuczwar, S.J. (2019). Ketogenic Diet in Alzheimer’s Disease. Int J Mol Sci, 20, 3892. [CrossRef] [PubMed] [Google Scholar]
  • Ryu, J. C., Zimmer, E. R., Rosa-Neto, P., Yoon, S. O. (2019). Consequences of Metabolic Disruption in Alzheimer’s Disease Pathology. Neurotherapeutics, 16, 600-610. [CrossRef] [PubMed] [Google Scholar]
  • Schönfeld, P., Wojtczak, L. (2016). Short- and medium-chain fatty acids in energy metabolism: The cellular perspective. J Lipid Res, 57, 943-954. [CrossRef] [PubMed] [Google Scholar]
  • Shippy, D.C., Wilhelm, C., Viharkumar, P.A., Raife, T.J., Ulland, T.K. (2020) β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology. J Neuroinflammation, 17, 280. [Google Scholar]
  • Simpson, I.A., Chundu, K.R., Davies-Hill, T., Honer, W.G., Davies, P. (1994). Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer’s disease. Ann Neurol, 35, 546-551. [CrossRef] [PubMed] [Google Scholar]
  • Sims, J.R., Zimmer, J.A., Evans, C.D., Lu, M., Ardayfio, P., Sparks, J., Wessels, A.M., Shcherbinin, S., Wang, H., Monkul Nery, E.S., Collins, E.C., Solomon, P., Salloway, S., Apostolova, L.G., Hansson, O., Ritchie, C., Brooks, D.A., Mintun, M., Skovronsky, D.M., TRAILBLAZER-ALZ 2 Investigators. (2023). Donanemab in Early Symptomatic Alzheimer Disease : The TRAILBLAZER-ALZ 2 Randomized Clinical Trial. JAMA, e2313239. [Google Scholar]
  • Soria Lopez, J.A., González, H.M., Léger, G.C. (2019). Alzheimer’s disease. Handb Clin Neurol, 167, 231-255. [CrossRef] [PubMed] [Google Scholar]
  • Stampfer, M.J. (2006). Cardiovascular disease and Alzheimer’s disease: Common links. J Intern Med, 260, 211-223. [CrossRef] [PubMed] [Google Scholar]
  • Stephen, R., Hongisto, K., Solomon, A., Lönnroos, E. (2017). Physical Activity and Alzheimer’s Disease: A Systematic Review. J Gerontol A Biol Sci Med Sci, 72, 733-739. [PubMed] [Google Scholar]
  • Straus, D. S., Glass, C. K. (2007). Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms. Trends Immunol, 28, 551-558. [CrossRef] [PubMed] [Google Scholar]
  • Sumithran, P., Proietto, J. (2008). Ketogenic diets for weight loss: A review of their principles, safety and efficacy. Obes Res Clin Pract, 2, 1-13. [CrossRef] [Google Scholar]
  • Swan, K., Hopper, M., Wenke, R., Jackson, C., Till, T., Conway, E. (2018). Speech-Language Pathologist Interventions for Communication in Moderate-Severe Dementia: A Systematic Review. Am J Speech Lang Pathol, 27, 836-852. [CrossRef] [MathSciNet] [Google Scholar]
  • Taylor, M.K., Sullivan, D.K., Mahnken, J.D., Burns, J.M., Swerdlow, R.H. (2018). Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s disease. Alzheimers Dement, 4, 28-36. [CrossRef] [Google Scholar]
  • Terada, T., Obi, T., Bunai, T., Matsudaira, T., Yoshikawa, E., Ando, I., Futatsubashi, M., Tsukada, H., Ouchi, Y. (2020). In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease. Neurology, 94, e1592-e1604. [CrossRef] [PubMed] [Google Scholar]
  • Turner, N., Hariharan, K., TidAng, J., Frangioudakis, G., Beale, S.M., Wright, L.E., Zeng, X.Y., Leslie, S.J., Li, J.-Y., Kraegen, E.W., Cooney, G.J., Ye, J.-M. (2009). Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent. Diabetes, 58, 2547-2554. [CrossRef] [PubMed] [Google Scholar]
  • Uemura, E., Greenlee, H.W. (2001). Amyloid β-Peptide Inhibits Neuronal Glucose Uptake by Preventing Exocytosis. Exp Neurol, 170, 270-276. [CrossRef] [PubMed] [Google Scholar]
  • Volkmer, A., Rogalski, E., Henry, M., Taylor-Rubin, C., Ruggero, L., Khayum, R., Kindell, J., Gorno-Tempini, M.L., Warren, J.D., Rohrer, J.D. (2020). Speech and language therapy approaches to managing primary progressive aphasia. Pract Neurol, 20, 154-161. [CrossRef] [PubMed] [Google Scholar]
  • Wang, Y., Liu, Z., Han, Y., Xu, J., Huang, W., Li, Z. (2018). Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. PLoS ONE, 13, e0191182. [CrossRef] [PubMed] [Google Scholar]
  • Wang, Y., Zhang, J., Zhang, Y., Yao, J. (2023). Bibliometric analysis of global research profile on ketogenic diet therapies in neurological diseases : Beneficial diet therapies deserve more attention. Front Endocrinol (Lausanne), 13, 1066785. [CrossRef] [PubMed] [Google Scholar]
  • Wegmann, S., Biernat, J., Mandelkow, E. (2021). A current view on Tau protein phosphorylation in Alzheimer’s disease. Curr Opin Neurobiol, 69, 131-138. [CrossRef] [PubMed] [Google Scholar]
  • Whitelock, E., Ensaff, H. (2018). On Your Own: Older Adults’ Food Choice and Dietary Habits. Nutrients, 10, 413. [CrossRef] [PubMed] [Google Scholar]
  • Winkler, E.A., Nishida, Y., Sagare, A P., Rege, S.V., Bell, R.D., Perlmutter, D., Sengillo, J.D., Hillman, S., Kong, P., Nelson, A.R., Sullivan, J.S., Zhao, Z., Meiselman, H.J., Wenby, R.B., Soto, J., Abel, E.D., Makshanoff, J., Zuniga, E., De Vivo, D.C., Zlokovic, B.V. (2015). GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci, 18, 521-530. [CrossRef] [PubMed] [Google Scholar]
  • Wirrell, E., Eckert, S., Wong-Kisiel, L., Payne, E., Nickels, K. (2018). Ketogenic diet therapy in infants : Efficacy and tolerability. Pediatr Neurol, 82, 13-18 [CrossRef] [PubMed] [Google Scholar]
  • Włodarek, D. (2019). Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease). Nutrients, 11, 169. [CrossRef] [PubMed] [Google Scholar]
  • Wu, Y., Chen, M., Jiang, J. (2019). Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion, 49, 35-45. [CrossRef] [PubMed] [Google Scholar]
  • Xie, G., Tian, W., Wei, T., Liu, F. (2015). The neuroprotective effects of β-hydroxybutyrate on Aβ-injected rat hippocampus in vivo and in Aβ-treated PC-12 cells in vitro. Free Rad Res, 49, 139-150. [CrossRef] [PubMed] [Google Scholar]
  • Xu, Y., Jiang, C., Wu, J., Liu, P., Deng, X., Zhang, Y., Peng, B., Zhu, Y. (2022). Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer’s disease. CNS Neurosci Ther, 28, 580-592. [Google Scholar]
  • Yang, X., Cheng, B. (2010). Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity. J Mol Neurosci, 42, 145-153. [CrossRef] [PubMed] [Google Scholar]
  • Yin, F., Sancheti, H., Patil, I., Cadenas, E. (2016). Energy metabolism and inflammation in brain aging and Alzheimer’s disease. Free Radic Biol Med, 100, 108-122. [CrossRef] [PubMed] [Google Scholar]
  • Youm, Y.-H., Nguyen, K.Y., Grant, R.W., Goldberg, E.L., Bodogai, M., Kim, D., D’Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T.D., Kang, S., Horvath, T.L., Fahmy, T.M., Crawford, P.A., Biragyn, A., Alnemri, E., Dixit, V.D. (2015). Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease. Nat Med, 21, 263-269. [CrossRef] [PubMed] [Google Scholar]
  • Yuan, X., Wang, J., Yang, S., Gao, M., Cao, L., Li, X., Hong, D., Tian, S., Sun, C. (2020). Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: A systematic review and meta-analysis. Nutr Diabetes, 10, 38. [CrossRef] [MathSciNet] [PubMed] [Google Scholar]
  • Zandi-Nejad, K., Takakura, A., Jurewicz, M., Chandraker, A.K., Offermanns, S., Mount, D., Abdi, R. (2013). The role of HCA2 (GPR109A) in regulating macrophage function. FASEB J, 27, 4366-4374. [CrossRef] [PubMed] [Google Scholar]
  • Zhang, C., Rissman, R. A., Feng, J. (2015). Characterization of ATP Alternations in an Alzheimer’s Disease Transgenic Mouse Model. J Alzheimers Dis, 44, 375-378. [CrossRef] [PubMed] [Google Scholar]
  • Zhang, H., Wei, W., Zhao, M., Ma, L., Jiang, X., Pei, H., Cao, Y., Li, H. (2021). Interaction between Aβ and Tau in the Pathogenesis of Alzheimer’s Disease. Int J Biol Sci, 17, 2181-2192. [CrossRef] [PubMed] [Google Scholar]
  • Zhong, N., Weisgraber, K. H. (2009). Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure. J Biol Chem, 284, 6027-6031. [CrossRef] [PubMed] [Google Scholar]
  • Zhu, Y., Shan, X., Yuzwa, S.A., Vocadlo, D.J. (2014). The Emerging Link between O-GlcNAc and Alzheimer Disease. J Biol Chem, 289, 34472-34481. [CrossRef] [PubMed] [Google Scholar]
  • Ziegler, D.R., Ribeiro, L.C., Hagenn, M., Siqueira, I.R., Araújo, E., Torres, I.L.S., Gottfried, C., Netto, C.A., Gonçalves, C.-A. (2003). Ketogenic diet increases glutathione peroxidase activity in rat hippocampus. Neurochem Res, 28, 1793-1797. [CrossRef] [PubMed] [Google Scholar]

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