Free Access
| Issue |
Biologie Aujourd’hui
Volume 217, Number 3-4, 2023
|
|
|---|---|---|
| Page(s) | 253 - 263 | |
| DOI | https://doi.org/10.1051/jbio/2023031 | |
| Published online | 29 novembre 2023 | |
- Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W. S. T., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I. R., McGeer, P.L., O’Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Van Muiswinkel, F. L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., Wyss-Coray, T. (2000). Inflammation and Alzheimer’s disease. Neurobiol Aging, 21, 383-421. [CrossRef] [PubMed] [Google Scholar]
- Alarim, R.A., Alasmre, F.A., Alotaibi, H.A., Alshehri, M.A., Hussain, S.A. (2020). Effects of the Ketogenic Diet on Glycemic Control in Diabetic Patients: Meta-Analysis of Clinical Trials. Cureus, 12, e10796. [PubMed] [Google Scholar]
- An, Y., Varma, V. R., Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, C. W., Egan, J. M., Ferrucci, L., Troncoso, J., Levey, A. I., Lah, J., Seyfried, N. T., Legido-Quigley, C., O’Brien, R., Thambisetty, M. (2018). Evidence for brain glucose dysregulation in Alzheimer’s disease. Alzheimers Dement, 14, 318-329. [CrossRef] [PubMed] [Google Scholar]
- Audinat, É., Arnoux, I. (2014). La microglie : des cellules immunitaires qui sculptent et contrôlent les synapses neuronales. Med Sci, 30, 153-159. [Google Scholar]
- Augustin, K., Khabbush, A., Williams, S., Eaton, S., Orford, M., Cross, J. H., Heales, S.J.R., Walker, M.C., Williams, R.S.B. (2018). Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders. Lancet Neurol, 17, 84-93. [CrossRef] [PubMed] [Google Scholar]
- Bach, A., Schirardin, H., Weryha, A., Bauer, M. (1977). Ketogenic Response to Medium-Chain Triglyceride Load in the Rat. J Nutr, 107, 1863-1870. [CrossRef] [PubMed] [Google Scholar]
- Benito, A., Hajji, N., O’Neill, K., Keun, H. C., Syed, N. (2020). β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells. Metabolites, 26, 346. [CrossRef] [PubMed] [Google Scholar]
- Benoit, M., Staccini, P., Brocker, P., Benhamidat, T., Bertogliati, C., Lechowski, L., Tortrat, D., Robert, P. H. (2003). Symptômes comportementaux et psychologiques dans la maladie d’ Alzheimer : Résultats de l’étude REAL.FR. Rev Med Interne, 24, 319s-324s. [CrossRef] [PubMed] [Google Scholar]
- Bielohuby, M., Sisley, S., Sandoval, D., Herbach, N., Zengin, A., Fischereder, M., Menhofer, D., Stoehr, B.J.M., Stemmer, K., Wanke, R., Tschöp, M.H., Seeley, R.J., Bidlingmaier, M. (2013). Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab., 305, E1059-E1070. [CrossRef] [PubMed] [Google Scholar]
- Blazhenets, G., Frings, L., Ma, Y., Sörensen, A., Eidelberg, D., Wiltfang, J., Meyer, P.T., for the Alzheimer’s Disease Neuroimaging Initiative. (2021). Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration. Neurology, 96, e1358-e1368. [CrossRef] [PubMed] [Google Scholar]
- Brandt, J., Buchholz, A., Henry-Barron, B., Vizthum, D., Avramopoulos, D., Cervenka, M. C. (2019). Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease. J Alzheimers Dis, 68, 969-981. [CrossRef] [PubMed] [Google Scholar]
- Butterfield, D. A., Halliwell, B. (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci, 20, 148-160. [CrossRef] [PubMed] [Google Scholar]
- Castro, C.B., Dias, C.B., Hillebrandt, H., Sohrabi, H.R., Chatterjee, P., Shah, T.M., Fuller, S.J., Garg, M.L., Martins, R.N. (2023). Medium-chain fatty acids for the prevention or treatment of Alzheimer’s disease : a systematic review and meta-analysis. Nutr Rev, nuac104. [Google Scholar]
- Charlot, A., Conrad, O., Zoll, J. (2020). Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ? Biol Aujourdhui, 214, 115-123. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
- Charlot, A., Boumiza, R., Roux, M., Zoll, J. (2021). Obésité, inflammation et COVID-19 : intérêt préventif de l’alimentation cétogène ? Biol Aujourdhui, 215, 63-72. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
- Charlot, A., Morel, L., Bringolf, A., Georg, I., Charles, A.L., Goupilleau, F., Geny, B., Zoll, J. (2022). Octanoic Acid-Enrichment Diet Improves Endurance Capacity and Reprograms Mitochondrial Biogenesis in Skeletal Muscle of Mice. Nutrients, 14, 2721. [CrossRef] [PubMed] [Google Scholar]
- Charlot, A., Zoll, J. (2022). Beneficial Effects of the Ketogenic Diet in Metabolic Syndrome: A Systematic Review. Diabetology, 3, 292-309. [CrossRef] [Google Scholar]
- Cheng, Y., Bai, F. (2018). The Association of Tau with Mitochondrial Dysfunction in Alzheimer’s Disease. Front Neurosci, 12, 163. [CrossRef] [PubMed] [Google Scholar]
- Conti Filho, C.E., Loss, L.B., Marcolongo-Pereira, C., Rossoni Junior, J.V., Barcelos, R.M., Chiarelli-Neto, O., da Silva, B.S., Passamani Ambrosio, R., Castro, F.C.A.Q., Teixeira, S.F., Mezzomo, N.J. (2023). Advances in Alzheimer’s disease’s pharmacological treatment. Front Pharmacol, 26, 14, 1101452. [CrossRef] [PubMed] [Google Scholar]
- Croteau, E., Castellano, C.-A., Richard, M. A., Fortier, M., Nugent, S., Lepage, M., Duchesne, S., Whittingstall, K., Turcotte, É. E., Bocti, C., Fülöp, T., Cunnane, S. C. (2018). Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease. J Alzheimers Dis, 64, 551-561. [CrossRef] [PubMed] [Google Scholar]
- De la Rosa, A., Olaso-Gonzalez, G., Arc-Chagnaud, C., Millan, F., Salvador-Pascual, A., García-Lucerga, C., Blasco-Lafarga, C., Garcia-Dominguez, E., Carretero, A., Correas, A.G., Viña, J., Gomez-Cabrera, M. C. (2020). Physical exercise in the prevention and treatment of Alzheimer’s disease. J Sport Health Sci, 9, 394-404. [CrossRef] [PubMed] [Google Scholar]
- Diniz, B.S., Butters, M.A., Albert, S.M., Dew, M.A., Reynolds, C.F. (2013). Late-life depression and risk of vascular dementia and Alzheimer’s disease: Systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry, 202, 329-335. [CrossRef] [PubMed] [Google Scholar]
- Drewnowski, A., Shultz, J. M. (2001). Impact of aging on eating behaviors, food choices, nutrition, and health status. J Nutr Health Aging, 5, 75-79. [PubMed] [Google Scholar]
- Du, H., Guo, L., Yan, S., Sosunov, A.A., McKhann, G.M., Shi Du Yan, S. (2010). Early deficits in synaptic mitochondria in an Alzheimer’s disease mouse model. Proc Natl Acad Sci USA, 107, 18670-18675. [CrossRef] [PubMed] [Google Scholar]
- Dupuis, N., Curatolo, N., Benoist, J.-F., Auvin, S. (2015). Ketogenic diet exhibits anti-inflammatory properties. Epilepsia, 56, e95-e98. [PubMed] [Google Scholar]
- Ebanks, B., Ingram, T.L., Chakrabarti, L. (2020). ATP synthase and Alzheimer’s disease: Putting a spin on the mitochondrial hypothesis. Aging (Albany NY), 12, 16647-16662. [CrossRef] [PubMed] [Google Scholar]
- Ellenbroek, J.H., van Dijck, L., Töns, H.A., Rabelink, T.J., Carlotti, F., Ballieux, B.E.P.B., de Koning, E.J.P. (2014). Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice. Am J Physiol Endocrinol Metab, 306, E552-E558. [CrossRef] [PubMed] [Google Scholar]
- Fortier, M., Castellano, C.-A., Croteau, E., Langlois, F., Bocti, C., St-Pierre, V., Vandenberghe, C., Bernier, M., Roy, M., Descoteaux, M., Whittingstall, K., Lepage, M., Turcotte, É.E., Fulop, T., Cunnane, S.C. (2019). A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimers Dement, 15, 625-634. [CrossRef] [PubMed] [Google Scholar]
- Gatz, M., Reynolds, C.A., Fratiglioni, L., Johansson, B., Mortimer, J.A., Berg, S., Fiske, A., Pedersen, N.L. (2006). Role of Genes and Environments for Explaining Alzheimer Disease. Arch Gen Psychiatry, 63, 168. [CrossRef] [PubMed] [Google Scholar]
- Goldberg, E.L., Asher, J.L., Molony, R.D., Shaw, A.C., Zeiss, C.J., Wang, C., Morozova-Roche, L.A., Herzog, R.I., Iwasaki, A., Dixit, V. D. (2017). β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep, 18, 2077-2087. [CrossRef] [PubMed] [Google Scholar]
- Gómora-García, J.C., Montiel, T., Hüttenrauch, M., Salcido-Gómez, A., García-Velázquez, L., Ramiro-Cortés, Y., Gomora, J.C., Castro-Obregón, S., Massieu, L. (2023). Effect of the Ketone Body, D-β-Hydroxybutyrate, on Sirtuin2-Mediated Regulation of Mitochondrial Quality Control and the Autophagy-Lysosomal Pathway. Cells, 12, 486. [CrossRef] [PubMed] [Google Scholar]
- Goss, A.M., Gower, B., Soleymani, T., Stewart, M., Pendergrass, M., Lockhart, M., Krantz, O., Dowla, S., Bush, N., Garr Barry, V., Fontaine, K.R. (2020). Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: A randomized clinical trial. Nutr Metab (Lond), 17, 64. [CrossRef] [PubMed] [Google Scholar]
- Gough, S.M., Casella, A., Ortega, K.J., Hackam, A.S. (2021). Neuroprotection by the Ketogenic Diet : Evidence and Controversies. Front Nutr, 8, 782657. [CrossRef] [PubMed] [Google Scholar]
- Grandl, G., Straub, L., Rudigier, C., Arnold, M., Wueest, S., Konrad, D., Wolfrum, C. (2018). Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet. J Physiol, 596, 4597-4609. [CrossRef] [PubMed] [Google Scholar]
- Greenwood, C.E., Parrott, M.D. (2017). Nutrition as a component of dementia risk reduction strategies. Health Manage Forum, 30, 40-45. [CrossRef] [PubMed] [Google Scholar]
- Haces, M.L., Hernández-Fonseca, K., Medina-Campos, O.N., Montiel, T., Pedraza-Chaverri, J., Massieu, L. (2008). Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions. Exp Neurol, 211, 85-96. [CrossRef] [PubMed] [Google Scholar]
- Harvey, C.C.J., Schofield, G.M., Williden, M., McQuillan, J.A. (2018). The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial. J Nutr Metab, 2018, 2630565. [CrossRef] [Google Scholar]
- Hasan-Olive, M.M., Lauritzen, K.H., Ali, M., Rasmussen, L.J., Storm-Mathisen, J.,Bergersen, L.H. (2019). A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis. Neurochem Res, 44, 22-37. [CrossRef] [PubMed] [Google Scholar]
- Haute Autorité de Santé [Internet]. (2007). Stratégie de prise en charge en cas de dénutrition protéino-énergétique chez la personne âgée. Haute Autorité de Santé. Disponible sur : https://www.has-sante.fr/jcms/c_546549/fr/strategie-de-prise-en-charge-en-cas-de-denutrition-proteino-energetique-chez-la-personne-agee. [Google Scholar]
- Heneka, M.T., Carson, M.J., El Khoury, J., Landreth, G.E., Brosseron, F., Feinstein, D.L., Jacobs, A.H., Wyss-Coray, T., Vitorica, J., Ransohoff, R.M., Herrup, K., Frautschy, S.A., Finsen, B., Brown, G.C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., Petzold, G.C., Town, T., Morgan, D., Shinohara, M.L., Perry, V.H., Holmes, C., Bazan, N.G., Brooks, D.J., Hunot, S., Joseph, B., Deigendesch, N., Garaschuk, O., Boddeke, E., Dinarello, C.A., Breitner, J.C., Cole, G.M., Golenbock, D.T., Kummer, M.P. (2015). Neuroinflammation in Alzheimer’s Disease. Lancet Neurol, 14, 388-405. [CrossRef] [PubMed] [Google Scholar]
- Herholz, K. (2010). Cerebral glucose metabolism in preclinical and prodromal Alzheimer’s disease. Expert Rev Neurother, 10, 1667-1673. [CrossRef] [PubMed] [Google Scholar]
- Hersant, H., Grossberg, G. (2022). The Ketogenic Diet and Alzheimer’s Disease. J Nutr Health Aging, 26, 606–614. [CrossRef] [PubMed] [Google Scholar]
- Hou, Y., Moreau, F., Chadee, K. (2012). PPARγ is an E3 ligase that induces the degradation of NFκB/p65. Nat Commun, 3, 1300. [CrossRef] [PubMed] [Google Scholar]
- INSERM [Internet]. (2006). Orphanet : syndrome de déficit en transporteur du glucose de type 1, forme classique. Disponible sur : https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=71277. [Google Scholar]
- Jack, C.R., Bennett, D.A., Blennow, K., Carrillo, M.C., Dunn, B., Haeberlein, S.B., Holtzman, D.M., Jagust, W., Jessen, F., Karlawish, J., Liu, E., Molinuevo, J.L., Montine, T., Phelps, C., Rankin, K. P., Rowe, C.C., Scheltens, P., Siemers, E., Snyder, H.M., Sperling, R. (2018). NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement, 14, 535-562. [CrossRef] [PubMed] [Google Scholar]
- Jensen, N. J., Wodschow, H. Z., Nilsson, M., Rungby, J. (2020). Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. Int J Mol Sci, 21, 8767. [CrossRef] [PubMed] [Google Scholar]
- Koepsell, H. (2020). Glucose transporters in brain in health and disease. Pflügers Arch, 472, 1299-1343. [CrossRef] [PubMed] [Google Scholar]
- Kondo, K., Kikuta, S., Ueha, R., Suzukawa, K., Yamasoba, T. (2020). Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management. Front Aging Neurosci, 12, 208. [CrossRef] [PubMed] [Google Scholar]
- Kong, G., Wang, J., Li, R., Huang, Z., Wang, L. (2022). Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther, 24, 113. [CrossRef] [PubMed] [Google Scholar]
- Krikorian, R., Shidler, M.D., Dangelo, K., Couch, S.C., Benoit, S.C., Clegg, D.J. (2012). Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging, 33, 425.e19-425.e27. [CrossRef] [PubMed] [Google Scholar]
- Kumar, S., Behl, T., Sachdeva, M., Sehgal, A., Kumari, S., Kumar, A., Kaur, G., Yadav, H.N., Bungau, S. (2021). Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus. Life Sci, 264, 118661. [CrossRef] [PubMed] [Google Scholar]
- Leibson, C.L., Rocca, W.A., Hanson, V.A., Cha, R., Kokmen, E., O’Brien, P. C., Palumbo, P.J. (1997). Risk of dementia among persons with diabetes mellitus: A population-based cohort study. Am J Epidemiol, 145, 301-308. [CrossRef] [PubMed] [Google Scholar]
- Lilamand, M., Mouton-Liger, F., Di Valentin, E., Sànchez Ortiz, M., Paquet, C. (2022). Efficacy and Safety of Ketone Supplementation or Ketogenic Diets for Alzheimer’s Disease: A Mini Review. Front Nutr, 8, 807970. [CrossRef] [PubMed] [Google Scholar]
- Liu, Y. C., Wang, H.-S. (2013). Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets. Biomed J, 36, 9-15. [CrossRef] [PubMed] [Google Scholar]
- Loughman, A., Staudacher, H. M., Rocks, T., Ruusunen, A., Marx, W., O Apos Neil, A., Jacka, F.N. (2021). Diet and Mental Health. Mod Trends Psychiatry, 32, 100-112. [CrossRef] [PubMed] [Google Scholar]
- Lyons, L., Schoeler, N.E., Langan, D., Cross, J. H. (2020). Use of ketogenic diet therapy in infants with epilepsy : A systematic review and meta-analysis. Epilepsia, 61, 1261-1281 [CrossRef] [PubMed] [Google Scholar]
- Majou, D. (2015). Alzheimer’s disease: Origins, mechanisms, people at risk and prevention by DHA (omega-3 fatty acid). Actia Editions. [Google Scholar]
- Manczak, M., Anekonda, T.S., Henson, E., Park, B.S., Quinn, J., Reddy, P.H. (2006). Mitochondria are a direct site of a beta accumulation in Alzheimer’s disease neurons: Implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet, 15, 1437-1449. [CrossRef] [PubMed] [Google Scholar]
- Marucci, G., Buccioni, M., Ben, D.D., Lambertucci, C., Volpini, R., Amenta, F. (2021). Efficacy of acetylcholinesterase inhibitors in Alzheimer’s disease. Neuropharmacology, 190, 108352. [CrossRef] [PubMed] [Google Scholar]
- Mergenthaler, P., Lindauer, U., Dienel, G. A., Meisel, A. (2013). Sugar for the brain: The role of glucose in physiological and pathological brain function. Trends Neurosci, 36, 587-597. [CrossRef] [PubMed] [Google Scholar]
- Meyer-Rogge, S., Meyer-Rogge, K. (2012). Biochimie métabolique. De Boeck. ISBN 978-2-8041-7147-6 [Google Scholar]
- Moriconi, E., Camajani, E., Fabbri, A., Lenzi, A., Caprio, M. (2021). Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes. Nutrients, 13, 758. [CrossRef] [PubMed] [Google Scholar]
- Mosconi, L. (2005). Brain glucose metabolism in the early and specific diagnosis of Alzheimers disease: FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging, 32, 486-510. [CrossRef] [MathSciNet] [PubMed] [Google Scholar]
- Nakao, R., Abe, T., Yamamoto, S., Oishi, K. (2019). Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice. Sci Rep, 9, 19652. [CrossRef] [PubMed] [Google Scholar]
- Nishida, Y., Winkler, E., Sagare, A., De Vivo, D., Zlokovic, B. (2017). Decreased glucose transporter 1 expression at the blood-brain barrier exacerbates Alzheimer disease-like phenotypes in mouse models. J Neurol Sci, 381, 768. [CrossRef] [Google Scholar]
- Norgren, J., Sindi, S., Sandebring-Matton, A., Kåreholt, I., Daniilidou, M., Akenine, U., Nordin, K., Rosenborg, S., Ngandu, T., Kivipelto, M. (2020). Ketosis after Intake of Coconut Oil and Caprylic Acid—With and Without Glucose: A Cross-Over Study in Healthy Older Adults. Front Nutr, 7, 40. [CrossRef] [PubMed] [Google Scholar]
- Organisation mondiale de la santé [Internet]. (2020). La démence. Organisation mondiale de la santé. Disponible sur : https://www.who.int/fr/news-room/fact-sheets/detail/dementia. [Google Scholar]
- Ota, M., Matsuo, J., Ishida, I., Takano, H., Yokoi, Y., Hori, H., Yoshida, S., Ashida, K., Nakamura, K., Takahashi, T., Kunugi, H. (2019). Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease. Neurosci Lett, 690, 232-236. [CrossRef] [PubMed] [Google Scholar]
- Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., Martínez-Lage, P. (2014). Diet, cognition, and Alzheimer’s disease: Food for thought. Eur J Nutr, 53, 1-23. [CrossRef] [Google Scholar]
- Parker, W. D. (1991). Cytochrome oxidase deficiency in Alzheimer’s disease. Ann N Y Acad Sci, 640, 59-64. [CrossRef] [PubMed] [Google Scholar]
- Perez Ortiz, J.M., Swerdlow, R.H. (2019). Mitochondrial dysfunction in Alzheimer’s disease: Role in pathogenesis and novel therapeutic opportunities. Br J Pharmacol, 176, 3489-3507. [CrossRef] [PubMed] [Google Scholar]
- Prasuhn, J., Davis, R.L., Kumar, K.R. (2021). Targeting Mitochondrial Impairment in Parkinson’s Disease : Challenges and Opportunities. Front Cell Dev Biol, 8, 615461. [CrossRef] [PubMed] [Google Scholar]
- Rahman, M., Muhammad, S., Khan, M.A., Chen, H., Ridder, D.A., Müller-Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., Okun, J. G., Offermanns, S., Schwaninger, M. (2014). The β-hydroxybutyrate receptor HCA 2 activates a neuroprotective subset of macrophages. Nat Commun, 5, 1-11. [CrossRef] [Google Scholar]
- Rahman, A., Hossen, M.A., Chowdhury, M.F.I., Bari, S., Tamanna, N., Sultana, S.S., Haque, S.N., Al Masud, A., Saif-Ur-Rahman, K.M. (2023). Aducanumab for the treatment of Alzheimer’s disease : a systematic review. Psychogeriatrics, 23, 512-522. [CrossRef] [PubMed] [Google Scholar]
- Reger, M.A., Henderson, S.T., Hale, C., Cholerton, B., Baker, L.D., Watson, G.S., Hyde, K., Chapman, D., Craft, S. (2004). Effects of β-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging, 25, 311-314. [CrossRef] [PubMed] [Google Scholar]
- Rojas-Morales, P., Pedraza-Chaverri, J., Tapia, E. (2020) Ketone bodies, stress response, and redox homeostasis. Redox Biol, 29, 101395. [CrossRef] [PubMed] [Google Scholar]
- Rusek, M., Pluta, R., Ułamek-Kozioł, M., Czuczwar, S.J. (2019). Ketogenic Diet in Alzheimer’s Disease. Int J Mol Sci, 20, 3892. [CrossRef] [PubMed] [Google Scholar]
- Ryu, J. C., Zimmer, E. R., Rosa-Neto, P., Yoon, S. O. (2019). Consequences of Metabolic Disruption in Alzheimer’s Disease Pathology. Neurotherapeutics, 16, 600-610. [CrossRef] [PubMed] [Google Scholar]
- Schönfeld, P., Wojtczak, L. (2016). Short- and medium-chain fatty acids in energy metabolism: The cellular perspective. J Lipid Res, 57, 943-954. [CrossRef] [PubMed] [Google Scholar]
- Shippy, D.C., Wilhelm, C., Viharkumar, P.A., Raife, T.J., Ulland, T.K. (2020) β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology. J Neuroinflammation, 17, 280. [Google Scholar]
- Simpson, I.A., Chundu, K.R., Davies-Hill, T., Honer, W.G., Davies, P. (1994). Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer’s disease. Ann Neurol, 35, 546-551. [CrossRef] [PubMed] [Google Scholar]
- Sims, J.R., Zimmer, J.A., Evans, C.D., Lu, M., Ardayfio, P., Sparks, J., Wessels, A.M., Shcherbinin, S., Wang, H., Monkul Nery, E.S., Collins, E.C., Solomon, P., Salloway, S., Apostolova, L.G., Hansson, O., Ritchie, C., Brooks, D.A., Mintun, M., Skovronsky, D.M., TRAILBLAZER-ALZ 2 Investigators. (2023). Donanemab in Early Symptomatic Alzheimer Disease : The TRAILBLAZER-ALZ 2 Randomized Clinical Trial. JAMA, e2313239. [Google Scholar]
- Soria Lopez, J.A., González, H.M., Léger, G.C. (2019). Alzheimer’s disease. Handb Clin Neurol, 167, 231-255. [CrossRef] [PubMed] [Google Scholar]
- Stampfer, M.J. (2006). Cardiovascular disease and Alzheimer’s disease: Common links. J Intern Med, 260, 211-223. [CrossRef] [PubMed] [Google Scholar]
- Stephen, R., Hongisto, K., Solomon, A., Lönnroos, E. (2017). Physical Activity and Alzheimer’s Disease: A Systematic Review. J Gerontol A Biol Sci Med Sci, 72, 733-739. [PubMed] [Google Scholar]
- Straus, D. S., Glass, C. K. (2007). Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms. Trends Immunol, 28, 551-558. [CrossRef] [PubMed] [Google Scholar]
- Sumithran, P., Proietto, J. (2008). Ketogenic diets for weight loss: A review of their principles, safety and efficacy. Obes Res Clin Pract, 2, 1-13. [CrossRef] [Google Scholar]
- Swan, K., Hopper, M., Wenke, R., Jackson, C., Till, T., Conway, E. (2018). Speech-Language Pathologist Interventions for Communication in Moderate-Severe Dementia: A Systematic Review. Am J Speech Lang Pathol, 27, 836-852. [CrossRef] [MathSciNet] [Google Scholar]
- Taylor, M.K., Sullivan, D.K., Mahnken, J.D., Burns, J.M., Swerdlow, R.H. (2018). Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s disease. Alzheimers Dement, 4, 28-36. [CrossRef] [Google Scholar]
- Terada, T., Obi, T., Bunai, T., Matsudaira, T., Yoshikawa, E., Ando, I., Futatsubashi, M., Tsukada, H., Ouchi, Y. (2020). In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease. Neurology, 94, e1592-e1604. [CrossRef] [PubMed] [Google Scholar]
- Turner, N., Hariharan, K., TidAng, J., Frangioudakis, G., Beale, S.M., Wright, L.E., Zeng, X.Y., Leslie, S.J., Li, J.-Y., Kraegen, E.W., Cooney, G.J., Ye, J.-M. (2009). Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent. Diabetes, 58, 2547-2554. [CrossRef] [PubMed] [Google Scholar]
- Uemura, E., Greenlee, H.W. (2001). Amyloid β-Peptide Inhibits Neuronal Glucose Uptake by Preventing Exocytosis. Exp Neurol, 170, 270-276. [CrossRef] [PubMed] [Google Scholar]
- Volkmer, A., Rogalski, E., Henry, M., Taylor-Rubin, C., Ruggero, L., Khayum, R., Kindell, J., Gorno-Tempini, M.L., Warren, J.D., Rohrer, J.D. (2020). Speech and language therapy approaches to managing primary progressive aphasia. Pract Neurol, 20, 154-161. [CrossRef] [PubMed] [Google Scholar]
- Wang, Y., Liu, Z., Han, Y., Xu, J., Huang, W., Li, Z. (2018). Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. PLoS ONE, 13, e0191182. [CrossRef] [PubMed] [Google Scholar]
- Wang, Y., Zhang, J., Zhang, Y., Yao, J. (2023). Bibliometric analysis of global research profile on ketogenic diet therapies in neurological diseases : Beneficial diet therapies deserve more attention. Front Endocrinol (Lausanne), 13, 1066785. [CrossRef] [PubMed] [Google Scholar]
- Wegmann, S., Biernat, J., Mandelkow, E. (2021). A current view on Tau protein phosphorylation in Alzheimer’s disease. Curr Opin Neurobiol, 69, 131-138. [CrossRef] [PubMed] [Google Scholar]
- Whitelock, E., Ensaff, H. (2018). On Your Own: Older Adults’ Food Choice and Dietary Habits. Nutrients, 10, 413. [CrossRef] [PubMed] [Google Scholar]
- Winkler, E.A., Nishida, Y., Sagare, A P., Rege, S.V., Bell, R.D., Perlmutter, D., Sengillo, J.D., Hillman, S., Kong, P., Nelson, A.R., Sullivan, J.S., Zhao, Z., Meiselman, H.J., Wenby, R.B., Soto, J., Abel, E.D., Makshanoff, J., Zuniga, E., De Vivo, D.C., Zlokovic, B.V. (2015). GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci, 18, 521-530. [CrossRef] [PubMed] [Google Scholar]
- Wirrell, E., Eckert, S., Wong-Kisiel, L., Payne, E., Nickels, K. (2018). Ketogenic diet therapy in infants : Efficacy and tolerability. Pediatr Neurol, 82, 13-18 [CrossRef] [PubMed] [Google Scholar]
- Włodarek, D. (2019). Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease). Nutrients, 11, 169. [CrossRef] [PubMed] [Google Scholar]
- Wu, Y., Chen, M., Jiang, J. (2019). Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion, 49, 35-45. [CrossRef] [PubMed] [Google Scholar]
- Xie, G., Tian, W., Wei, T., Liu, F. (2015). The neuroprotective effects of β-hydroxybutyrate on Aβ-injected rat hippocampus in vivo and in Aβ-treated PC-12 cells in vitro. Free Rad Res, 49, 139-150. [CrossRef] [PubMed] [Google Scholar]
- Xu, Y., Jiang, C., Wu, J., Liu, P., Deng, X., Zhang, Y., Peng, B., Zhu, Y. (2022). Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer’s disease. CNS Neurosci Ther, 28, 580-592. [Google Scholar]
- Yang, X., Cheng, B. (2010). Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity. J Mol Neurosci, 42, 145-153. [CrossRef] [PubMed] [Google Scholar]
- Yin, F., Sancheti, H., Patil, I., Cadenas, E. (2016). Energy metabolism and inflammation in brain aging and Alzheimer’s disease. Free Radic Biol Med, 100, 108-122. [CrossRef] [PubMed] [Google Scholar]
- Youm, Y.-H., Nguyen, K.Y., Grant, R.W., Goldberg, E.L., Bodogai, M., Kim, D., D’Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T.D., Kang, S., Horvath, T.L., Fahmy, T.M., Crawford, P.A., Biragyn, A., Alnemri, E., Dixit, V.D. (2015). Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease. Nat Med, 21, 263-269. [CrossRef] [PubMed] [Google Scholar]
- Yuan, X., Wang, J., Yang, S., Gao, M., Cao, L., Li, X., Hong, D., Tian, S., Sun, C. (2020). Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: A systematic review and meta-analysis. Nutr Diabetes, 10, 38. [CrossRef] [MathSciNet] [PubMed] [Google Scholar]
- Zandi-Nejad, K., Takakura, A., Jurewicz, M., Chandraker, A.K., Offermanns, S., Mount, D., Abdi, R. (2013). The role of HCA2 (GPR109A) in regulating macrophage function. FASEB J, 27, 4366-4374. [CrossRef] [PubMed] [Google Scholar]
- Zhang, C., Rissman, R. A., Feng, J. (2015). Characterization of ATP Alternations in an Alzheimer’s Disease Transgenic Mouse Model. J Alzheimers Dis, 44, 375-378. [CrossRef] [PubMed] [Google Scholar]
- Zhang, H., Wei, W., Zhao, M., Ma, L., Jiang, X., Pei, H., Cao, Y., Li, H. (2021). Interaction between Aβ and Tau in the Pathogenesis of Alzheimer’s Disease. Int J Biol Sci, 17, 2181-2192. [CrossRef] [PubMed] [Google Scholar]
- Zhong, N., Weisgraber, K. H. (2009). Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure. J Biol Chem, 284, 6027-6031. [CrossRef] [PubMed] [Google Scholar]
- Zhu, Y., Shan, X., Yuzwa, S.A., Vocadlo, D.J. (2014). The Emerging Link between O-GlcNAc and Alzheimer Disease. J Biol Chem, 289, 34472-34481. [CrossRef] [PubMed] [Google Scholar]
- Ziegler, D.R., Ribeiro, L.C., Hagenn, M., Siqueira, I.R., Araújo, E., Torres, I.L.S., Gottfried, C., Netto, C.A., Gonçalves, C.-A. (2003). Ketogenic diet increases glutathione peroxidase activity in rat hippocampus. Neurochem Res, 28, 1793-1797. [CrossRef] [PubMed] [Google Scholar]
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.
