Le neuropeptide 26RFa : un nouveau régulateur de l’homéostasie énergétique

Free Access

Issue		Biologie Aujourd'hui Volume 210, Number 4, 2016


Page(s)		227 - 235
Section		Comment le cerveau contrôle-t-il notre équilibre énergétique ?
DOI		https://doi.org/10.1051/jbio/2016024
Published online		22 mars 2017

Allerton, T.D., Primeaux, S.D. (2015). QRFP-26 enhances insulin’s effects on glucose uptake in rat skeletal muscle cells. Peptides, 69, 77-79. [CrossRef] [PubMed] [Google Scholar]
Bäckberg, M., Hervieu, G., Wilson, S., Meister, B. (2002). Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur J Neurosci, 15, 315-328. [CrossRef] [PubMed] [Google Scholar]
Beck, B., Richy, S. (2009).Suppression of QRFP 43 in the hypothalamic ventromedial nucleus of Long-Evans rats fed a high-fat diet. Biochem Biophys Res Commun, 383, 78-82. [CrossRef] [PubMed] [Google Scholar]
Bonini, J.A., Jones, K.A., Adham, N., Forray, C., Artymyshyn, R., Durkin, M.M., Smith, K.E., Tamm, J.A., Boteju, L.W., Lakhlani, P.P., Raddatz, R., Yao, W.J., Ogozalek, K.L., Boyle, N., Kouranova, E.V., Quan, Y., Vaysse, P.J., Wetzel, J.M., Branchek, T.A., Gerald, C., Borowsky, B. (2000). Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J Biol Chem, 275, 39324-39331. [CrossRef] [PubMed] [Google Scholar]
Bruzzone, F., Lectez, B., Tollemer, H., Leprince, J., Dujardin, C., Rachidi, W., Chatenet, D., Baroncini, M., Beauvillain, J.C., Vallarino, M., Vaudry, H., Chartrel, N. (2006). Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. J Neurochem, 99, 616-27. [CrossRef] [PubMed] [Google Scholar]
Bruzzone, F., Lectez, B., Alexandre, D., Jégou, S., Mounien, L., Tollemer, H., Chatenet, D., Leprince, J., Vallarino, M., Vaudry, H., Chartrel, N. (2007). Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat. J Comp Neurol, 503, 573-591. [PubMed] [Google Scholar]
Butler, A.E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R.A., Butler, P.C. (2003). Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes, 52, 102-110. [PubMed] [Google Scholar]
Chartrel, N., Dujardin, C., Leprince, J., Desrues, L., Tonon, M.C., Cellier, E., Jouenne, T., Simonnet, G., Vaudry, H. (2002). Isolation, characterization and distribution of a novel neuropeptide, Rana RFamide (R-RFa), in the brain of the European green frog Rana esculenta. J Comp Neurol, 448, 111-127. [PubMed] [Google Scholar]
Chartrel, N., Dujardin, C., AnouarY., Leprince, J., Decker, A., Clerens, S., Do-Régo J.L., Vandesande, F., Llorens-Cortes, C., Costentin, J., Beauvillain, J.C., Vaudry, H. (2003). Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci USA, 100, 15247-15252. [CrossRef] [Google Scholar]
Chartrel, N., Alonzeau, J., Alexandre, D., Jeandel, L., Alvear-Perez, R., Leprince, J., Boutin, J., Vaudry, H., Anouar, Y., Llorens-Cortes, C. (2011).The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions. Front Neuroendocrinol, 32, 387-397. [CrossRef] [PubMed] [Google Scholar]
Chen, A., Chiu, C.N., Mosser, E.A., Kahn, S., Spence, R., Prober, D.A. (2016). QRFP and its receptors regulate locomotor activity and sleep in zebrafish. J Neurosci, 36, 1823-1840. [CrossRef] [PubMed] [Google Scholar]
Ciriello, J., McMurray, J.C., Babic, T., de Oliveira, C.V. (2003). Collateral axonal projections from hypothalamic hypocretin neurons to cardiovascular sites in nucleus ambiguus and nucleus tractus solitarius. Brain Res, 991, 133-141. [PubMed] [Google Scholar]
Davies, J., Chen, J., Pink, R., Carter, D., Saunders, N., Sotiriadis, G., Bai, B., Pan, Y., Howlett, D., Payne, A., Randeva, H., Karteris, E. (2015). Orexin receptors exert a neuroprotective effect in Alzheimer’s desease (AD) via heterodimerization with GPR103. Sci Rep, 5, 12584. [CrossRef] [PubMed] [Google Scholar]
Dockray, G.J. (2004). The expanding family of -RFamide peptides and their effects on feeding behavior. Exp Physiol, 89, 229-235. [PubMed] [Google Scholar]
Do Rego, J.C., Leprince, J., Chartrel, N., Vaudry, H., Costentin, J. (2006). Behavioral effects of 26RFamide and related peptides. Peptides, 27, 2715-2721. [CrossRef] [PubMed] [Google Scholar]
Dube, M.G., HorvathT.L., Kalra, P.S. (2000). Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides, 21, 1557-1560. [CrossRef] [PubMed] [Google Scholar]
Fukusumi, S., Yoshida, H., Fujii, R., Maruyama, M., Komatsu, H., Habata, Y., Shintani, Y., Hinuma, S., Fujino, M. (2003). A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem, 278, 46387-46395. [CrossRef] [PubMed] [Google Scholar]
Egido, E.M., Hernandez, R., Leprince, J., Chartrel, N., Vaudry, H., Marco, J., Silvestre, R.A. (2007). 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides, 28, 725-730. [CrossRef] [PubMed] [Google Scholar]
Galusca, B., Jeandel, L., Germain, N., Alexandre, D., Leprince, J., Anouar, Y., Estour, B., Chartrel, N. (2012). Plasma levels of the orexigenic neuropeptide 26RFa in two populations with low body weight: constitutional thinness and anorexia nervosa. Influence of bingeing/purging episodes. J Clin Endocrinol Metab, 97, 2012-2018. [PubMed] [Google Scholar]
Gouardères, C., Mazarguil, H., Mollereau, C., Chartrel, N., Leprince, J., Vaudry, H., Zajac, J.M. (2007). Functional differences between NPFF1 and NPFF2 receptor coupling: High intrinsic activities of RFamide-related peptides on stimulation of [³⁵S]GTPγS binding. Neuropharmacol, 52, 376-386. [CrossRef] [Google Scholar]
Granata, R., Settanni, F., Trovato, L., Gallo, D., Gesmundo, I., Nano, R., Gallo, M.P., Bergandi, L., Volante, M., Alloatti, G., Piemonti, L., Leprince, J., Papotti, M., Vaudry, H., Ong, H., Ghigo, E. (2014). RFamide Peptides 43RFa and 26RFa Both Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets but Exert Opposite Effects on Insulin Secretion. Diabetes, 63, 2380-2393. [PubMed] [Google Scholar]
Greenwood, H.C., Bloom, S.R., Murphy, K.G. (2011).Peptides and their potential role in the treatment of diabetes and obesity. Rev Diabet Stud, 8, 355-368. [PubMed] [Google Scholar]
Jiang, Y., Luo, L., Gustafson, E.L., Yadav, D., Laverty, M., Murgolo, N., Vassileva, G., Zeng, M., Laz, T.M., Behan, J., Qiu, P., Wang, L., Wang, S., Bayne, M., Greene, J., Monsma, F. Jr., Zhang, F.L. (2003). Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem, 278, 27652-27657. [CrossRef] [PubMed] [Google Scholar]
Kahn, S.E., Cooper, M.E., Del Prato, S. (2014). Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet, 383, 1068-1083. [CrossRef] [PubMed] [Google Scholar]
Kampe, J., Wiedmer, P., Pfluger, P.T., Castaneda, T.R., Burget, L., Mondala, H., Kerr, J., Liaw, C., Oldfield, B.J., Tschöp, M.H., Bagnol, D. (2006). Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. Brain Res, 1119, 133-149. [PubMed] [Google Scholar]
Lectez, B., Jeandel, L., El-Yamani, F.Z., Arthaud, S., Alexandre, D., Mardargent, A., Jégou, S., Mounien, L., Bizet, P., Magoul, R., Anouar, Y., Chartrel, N. (2009). The orexigenic activity of the hypothalamic neuropeptide 26RFa is mediated by the neuropeptide Y and proopiomelanocortin neurons of the arcuate nucleus. Endocrinology, 150, 2342-2350. [CrossRef] [PubMed] [Google Scholar]
Lee, D.K., Nguyen, T., Lynch, K.R., Cheng, R., Vanti, W.B., Arkhitko, O., Lewis, T., Evans, J.F., George, S.R., O’Dowd, B.F. (2001). Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275, 83-91. [Google Scholar]
Liu, Y., Zhang, Y., Li, S., Huang, W., Liu, X., Lu, D., Meng, Z., Lin, H. (2009). Molecular cloning and functional characterization of the first non-mammalian 26RFa/QRFP orthologue in goldfish, Carassius auratus. Mol Endocrinol, 303, 82-90. [Google Scholar]
López, M., Seoane, L.M., García Medel, C., Diéguez, C., Señarís, R. (2002). Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus. Neuroendocrinology, 75, 34-44. [CrossRef] [PubMed] [Google Scholar]
Moriya, R., Sano, H., Umeda, T., Ito, M., Takahashi, Y., Matsuda, M., Ishihara, A., Kanatani, A., Iwaasa, H. (2006). RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology, 147, 2916-2922. [CrossRef] [PubMed] [Google Scholar]
Mulumba, M., Jossart, C., Granata, R., Gallo, D., Escher, E., Ghigo, E., Servant, M.J., Marleau, S., Ong, H. (2010). GPR103b functions in the peripheral regulation of adipogenesis. Mol Endocrinol, 24, 1615-1625. [PubMed] [Google Scholar]
Mulumba, M., Granata, R., Marleau, S., Ong, H. (2015). QRFP-43 inhibits lipolysis by preventing ligand-induced complex formation between perilipin A, caveolin-1, the catalytic subunit of protein kinase and hormone-sensitive lipase in 3T3-L1 adipocytes. Biochim Biophys Acta, 1851, 657-666. [PubMed] [Google Scholar]
Patel, S.R., Murphy, K.G., Thompson, E.L., Patterson, M., Curtis, A.E., Ghatei, M.A., Bloom, S.R. (2008). Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. Endocrinology, 149, 4747-4754. [CrossRef] [PubMed] [Google Scholar]
Prévost G., Jeandel, L., Arabo, A., Coëffier, M., El Ouahli, M., Picot, M., Alexandre, D., Gobet, F., Leprince, J., Berrahmoune, H., Déchelotte, P., Malagon, M., Bonner, C., Kerr-Conte, J., Chigr, F., Lefebvre, H., Anouar, Y., Chartrel, N. (2015). The hypothalamic neuropeptide 26RFa acts as an incretin to regulate glucose homeostasis. Diabetes, 64, 2805-2816. [PubMed] [Google Scholar]
Primeaux, S.D., Blackmon, C., Barnes, M.J., Braymer, D., Bray, G.A. (2008). Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in rats. Peptides, 29, 1994-2000. [CrossRef] [PubMed] [Google Scholar]
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richarson, J.A., Kozlowski, G.P., Wilson, S., Arch, J.R., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J., Yanagisawa, M. (1998). Orexins and orexin receptors : a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell, 92, 573-585. [CrossRef] [PubMed] [Google Scholar]
Schreiber, A.L., Arceneaux III, K.P., Malbrue, R.A., Mouton, A.J., Chen, C.S., Bench, E.M., Braymer, H.D., Primeaux, S.D. (2016). The effects of high fat diet and oestradiol on hypothalamic prepro-QRFP mRNA expression in female rats. Neuropeptides, 58, 103-109. [PubMed] [Google Scholar]
Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S.C., Iguchi, H., Kawasawa, Y.I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R.X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M., Sakai, J. (2006). A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci USA, 103, 7438-7443. [CrossRef] [Google Scholar]
Tomer, Y., Dolan, L.M., Kahaly, G., Divers, J., D’Agostino, R.B., Imperatore, G., Dabelea, D., Marcovina, S., Black, M.H., Pihoker, C., Hasham, A., Hammerstad, S.S., Greenberg, D.A., Lotay, V., Zhang, W., Monti, M.C., Matheis, N. (2015). SEARCH for Diabetes in Youth Study. Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. J Autoimmun, 60, 32-39. [CrossRef] [PubMed] [Google Scholar]
Ukena, K., Tachibana, T., Iwakoshi-Ukena, E., Saito, Y., Minakata, H., Kawaguchi, R., Osugi, T., Tobari, Y., Leprince, J., Vaudry, H., Tsutsui, K. (2010). Identification, localization, and function of a novel hypothalamic neuropeptide, 26RFa, and its cognate receptor, G protein-coupled receptor-103. Endocrinology, 151, 2255-2264. [CrossRef] [PubMed] [Google Scholar]
Yamanaka, A., Kunii, K., Nambu, T., Tsujino, N., Sakai, A., Matsuzaki, I., Miwa, Y., Goto, K., Sakurai, T. (2000). Orexin-induced food intake involves neuropeptide Y pathway. Brain Res, 859, 404-409. [PubMed] [Google Scholar]
Zagoracz, O., Kovacs, A., Laszlo, K., Ollmann, T., Peczely, L., Lenard, L. (2015). Effect of direct QRFP-26 administration into the medial hypothalamic area on food intake in rats. Brain Res Bull, 118, 58-64. [CrossRef] [PubMed] [Google Scholar]
World Health Organization (2014). Obésité et surpoids. In: Aide Mémoire. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.