Figure 9
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Homo-PROTAC et RIBOTAC. A. Structure d’un homo-PROTAC ciblant la E3 ligase MDM2 (1) et d’un homo-PROTAC ciblant la E3 ligase VHL (2). Ces Homo-PROTAC ont été conçus pour provoquer l’auto-dégradation par le protéasome de chacune de ces ligases. B. Schématisation du mode d’action d’un RIBOTAC.
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