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Accueil Tous les numéros Volume 212 / Numéro 1-2 (2018) Biologie Aujourd'hui, 212 1-2 (2018) 27-33 References
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Biologie Aujourd'hui
Volume 212, Number 1-2, 2018
Page(s) 27 - 33
Section La signalisation dans des compartiments intracellulaires : un nouveau paradigme
DOI https://doi.org/10.1051/jbio/2018016
Published online 26 octobre 2018
  • Bazzani, L., Donnini, S., Giachetti, A., Christofori, G., Ziche, M. (2018). PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. Oncotarget, 9, 14939-14958. [PubMed] [Google Scholar]
  • Bitler, B.G., Goverdhan, A., Schroeder, J.A. (2010). MUC1 regulates nuclear localization and function of the epidermal growth factor receptor. J Cell Sci, 123, 1716-1723. [Google Scholar]
  • Blume-Jensen, P., Hunter, T. (2001). Oncogenic kinase signalling. Nature, 411, 355-365. [CrossRef] [PubMed] [Google Scholar]
  • Brand, T.M., Iida, M., Corrigan, K.L., Braverman, C.M., Coan, J.P., Flanigan, B.G., Stein, A.P., Salgia, R., Rolff, J., Kimple, R.J., Wheeler, D.L. (2017). The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor. Sci Signal, 10, 460. [Google Scholar]
  • Carpenter, G. (2000). The EGF receptor: a nexus for trafficking and signaling. Bioessays, 22, 697-707. [CrossRef] [PubMed] [Google Scholar]
  • Carpenter, G., Liao, H.J. (2013). Receptor tyrosine kinases in the nucleus. Cold Spring Harb Perspect Biol, 5, a008979. [CrossRef] [PubMed] [Google Scholar]
  • Dayde, D., Guerard, M., Perron, P., Hatat, A.S., Barrial, C., Eymin, B., Gazzeri, S. (2016). Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival. Oncogene, 35, 3986-3994. [Google Scholar]
  • Dittmann, K., Mayer, C., Fehrenbacher, B., Schaller, M., Raju, U., Milas, L., Chen, D.J., Kehlbach, R., Rodemann, H.P. (2005a). Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem, 280, 31182-31189. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Rodemann, H.P. (2005b). Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol, 76, 157-161. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Wanner, G., Kehlbach, R., Rodemann, H.P. (2007). The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. Radiother Oncol, 84, 328-334. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Kehlbach, R., Rodemann, H.P. (2008a). Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol Cancer , 7, 69. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Kehlbach, R., Rodemann, H.P. (2008b). The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport. Radiother Oncol , 86, 375-382. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Fehrenbacher, B., Schaller, M., Kehlbach, R., Rodemann, H.P. (2010). Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654. FEBS Lett , 584, 3878-3884. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Fehrenbacher, B., Schaller, M., Kehlbach, R., Rodemann, H.P. (2011). Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. Radiother Oncol , 99, 317-322. [CrossRef] [PubMed] [Google Scholar]
  • Dittmann, K., Mayer, C., Czemmel, S., Huber, S.M., Rodemann, H.P. (2017). New roles for nuclear EGFR in regulating the stability and translation of mRNAs associated with VEGF signaling. PLoS One , 12, e0189087. [CrossRef] [PubMed] [Google Scholar]
  • Du, Y., Shen, J., Hsu, J.L., Han, Z., Hsu, M.C., Yang, C.C., Kuo, H.P., Wang, Y.N., Yamaguchi, H., Miller, S.A., Hung, M.C. (2014). Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene , 33, 756-770. [Google Scholar]
  • Hadzisejdic, I., Mustac, E., Jonjic, N., Petkovic, M., Grahovac, B. (2010). Nuclear EGFR in ductal invasive breast cancer: correlation with cyclin-D1 and prognosis. Mod Pathol , 23, 392-403. [CrossRef] [PubMed] [Google Scholar]
  • Hanada, N., Lo, H.W., Day, C.P., Pan, Y., Nakajima, Y., Hung, M.C. (2006). Co-regulation of B-Myb expression by E2F1 and EGF receptor. Mol Carcinog , 45, 10-17. [CrossRef] [PubMed] [Google Scholar]
  • Hsu, S.C., Miller, S.A., Wang, Y., Hung, M.C. (2009). Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res , 1, 249-258. [PubMed] [Google Scholar]
  • Huang, W.C., Chen, Y.J., Li, L.Y., Wei, Y.L., Hsu, S.C., Tsai, S.L., Chiu, P.C., Huang, W.P., Wang, Y.N., Chen, C.H., Chang, W.C., Chang, W.C., Chen, A.J., Tsai, C.H., Hung, M.C. (2011). Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem, 286, 20558-20568. [CrossRef] [PubMed] [Google Scholar]
  • Hung, L.Y., Tseng, J.T., Lee, Y.C., Xia, W., Wang, Y.N., Wu, M.L., Chuang, Y.H., Lai, C.H., Chang, W.C. (2011). Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res , 36, 4337-4351 [Google Scholar]
  • Huo, L., Wang, Y.N., Xia, W., Hsu, S.C., Lai, C.C., Li, L.Y., Chang, W.C., Wang, Y., Hsu, M.C., Yu, Y.L., Huang, T.H., Ding, Q., Chen, C.H., Tsai, C.H., Hung, M.C. (2010). RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci USA , 107, 16125-16130. [CrossRef] [Google Scholar]
  • Iida, M., Brand, T.M., Campbell, D.A., Li, C., Wheeler, D.L. (2013). Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor. Oncogene , 32, 759-767. [Google Scholar]
  • Jaganathan, S., Yue, P., Paladino, D.C., Bogdanovic, J., Huo, Q., Turkson, J. (2011). A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells. PLoS One , 6, e19605. [CrossRef] [PubMed] [Google Scholar]
  • Kim, H.P., Yoon, Y.K., Kim, J.W., Han, S.W., Hur, H.S., Park, J., Lee, J.H., Oh, D.Y., Im, S.A., Bang, Y.J., Kim, T.Y. (2009). Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2. PLoS One, 4, e5933. [CrossRef] [Google Scholar]
  • Kwak, E.L., Sordella, R., Bell, D.W., Godin-Heymann, N., Okimoto, R.A., Brannigan, B.W., Harris, P.L., Driscoll, D.R., Fidias, P., Lynch, T.J., Rabindran, S.K., McGinnis, J.P., Wissner, A., Sharma, S.V., Isselbacher, K.J., Settleman, J., Haber, D.A. (2005). Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci USA , 102, 7665-7670. [CrossRef] [Google Scholar]
  • Lemmon, M.A., Schlessinger, J. (2010). Cell signaling by receptor tyrosine kinases. Cell , 141, 1117-1134. [CrossRef] [PubMed] [Google Scholar]
  • Li, C., Iida, M., Dunn, E.F., Ghia, A.J., Wheeler, D.L. (2009). Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene , 28, 3801-3813. [Google Scholar]
  • Li, C.F., Fang, F.M., Wang, J.M., Tzeng, C.C., Tai, H.C., Wei, Y.C., Li, S.H., Lee, Y.T., Wang, Y.H., Yu, S.C., Shiue, Y.L., Chu, P.Y., Wang, W.L., Chen, L.T., Huang, H.Y. (2012). EGFR nuclear import in gallbladder carcinoma: nuclear phosphorylated EGFR upregulates iNOS expression and confers independent prognostic impact. Ann Surg Oncol , 19, 443-454. [CrossRef] [PubMed] [Google Scholar]
  • Liao, H.J., Carpenter, G. (2009). Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor. Cancer Res , 69, 6179-6183. [Google Scholar]
  • Liccardi, G., Hartley, J.A., Hochhauser, D. (2011). EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res , 71, 1103-1114. [Google Scholar]
  • Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L., Hung, M.C. (2001). Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol , 3, 802-808. [CrossRef] [PubMed] [Google Scholar]
  • Lipponen, P., Eskelinen, M. (1994). Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis. Br J Cancer , 69, 1120-1125. [CrossRef] [PubMed] [Google Scholar]
  • Lo, H.W., Hsu, S.C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J.Y., Hung, M.C. (2005a). Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell, 7, 575-589. [CrossRef] [PubMed] [Google Scholar]
  • Lo, H.W., Xia, W., Wei, Y., Ali-Seyed, M., Huang, S.F., Hung, M.C. (2005b). Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res , 65, 338-348 [Google Scholar]
  • Lo, H.W., Ali-Seyed, M., Wu, Y., Bartholomeusz, G., Hsu, S.C., Hung, M.C. (2006). Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. J Cell Biochem, 98, 1570-1583. [CrossRef] [Google Scholar]
  • Lo, H.W., Cao, X., Zhu, H., Ali-Osman, F. (2010). Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Mol Cancer Res , 8, 232-245. [CrossRef] [PubMed] [Google Scholar]
  • Marti, U., Burwen, S.J., Wells, A., Barker, M.E., Huling, S., Feren, A.M., Jones, A.L. (1991). Localization of epidermal growth factor receptor in hepatocyte nuclei. Hepatology , 13, 15-20. [CrossRef] [PubMed] [Google Scholar]
  • Nishimura, Y., Yoshioka, K., Bereczky, B., Itoh, K. (2008). Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line. Mol Cancer , 7, 42. [CrossRef] [PubMed] [Google Scholar]
  • Packham, S., Lin, Y., Zhao, Z., Warsito, D., Rutishauser, D., Larsson, O. (2015). The nucleus-localized epidermal growth factor receptor is SUMOylated. Biochemistry , 54, 5157-5166. [CrossRef] [PubMed] [Google Scholar]
  • Psyrri, A., Yu, Z., Weinberger, P.M., Sasaki, C., Haffty, B., Camp, R., Rimm, D., Burtness, B.A. (2005). Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res , 11, 5856-5862. [CrossRef] [PubMed] [Google Scholar]
  • Schlessinger, J. (2000). Cell signaling by receptor tyrosine kinases. Cell , 103, 211-225. [CrossRef] [PubMed] [Google Scholar]
  • Shi, Y., Tao, Y., Jiang, Y., Xu, Y., Yan, B., Chen, X., Xiao, L., Cao, Y. (2012). Nuclear epidermal growth factor receptor interacts with transcriptional intermediary factor 2 to activate cyclin D1 gene expression triggered by the oncoprotein latent membrane protein 1. Carcinogenesis , 33, 1468-1478. [CrossRef] [PubMed] [Google Scholar]
  • Sorkin, A., von Zastrow, M. (2002). Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol , 3, 600-614. [CrossRef] [PubMed] [Google Scholar]
  • Sorkin, A., Goh, L.K. (2009). Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res , 315, 683-696. [CrossRef] [PubMed] [Google Scholar]
  • Tervahauta, A., Syrjanen, S., Syrjanen, K. (1994). Epidermal growth factor receptor, c-erbB-2 proto-oncogene and estrogen receptor expression in human papillomavirus lesions of the uterine cervix. Int J Gynecol Pathol , 13, 234-240. [CrossRef] [PubMed] [Google Scholar]
  • Traynor, A.M., Weigel, T.L., Oettel, K.R., Yang, D.T., Zhang, C., Kim, K., Salgia, R., Iida, M., Brand, T.M., Hoang, T., Campbell, T.C., Hernan, H.R., Wheeler, D.L. (2013). Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer. Lung Cancer , 81, 138-141. [CrossRef] [PubMed] [Google Scholar]
  • von Zastrow, M., Sorkin, A. (2007). Signaling on the endocytic pathway. Curr Opin Cell Biol , 19, 436-445. [CrossRef] [PubMed] [Google Scholar]
  • Wang, S.C., Nakajima, Y., Yu, Y.L., Xia, W., Chen, C.T., Yang, C.C., McIntush, E.W., Li, L.Y., Hawke, D.H., Kobayashi, R., Hung, M.C. (2006). Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol , 8, 1359-1368. [CrossRef] [PubMed] [Google Scholar]
  • Wang, Y.N., Wang, H., Yamaguchi, H., Lee, H.J., Lee, H.H., Hung, M.C. (2010a). COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun , 399, 498-504. [Google Scholar]
  • Wang, Y.N., Yamaguchi, H., Hsu, J.M., Hung, M.C. (2010b). Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene , 29, 3997-4006. [Google Scholar]
  • Wang, Y.N., Yamaguchi, H., Huo, L., Du, Y., Lee, H.J., Lee, H.H., Wang, H., Hsu, J.M., Hung, M.C. (2010c). The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem , 285, 38720-38729. [CrossRef] [PubMed] [Google Scholar]
  • Wanner, G., Mayer, C., Kehlbach, R., Rodemann, H.P., Dittmann, K. (2008). Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiother Oncol , 86, 383-390. [CrossRef] [PubMed] [Google Scholar]
  • Wheeler, D.L., Iida, M., Kruser, T.J., Nechrebecki, M.M., Dunn, E.F., Armstrong, E.A., Huang, S., Harari, P.M. (2009). Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab. Cancer Biol Ther , 8, 696-703. [CrossRef] [PubMed] [Google Scholar]
  • Xia, W., Wei, Y., Du, Y., Liu, J., Chang, B., Yu, Y.L., Huo, L.F., Miller, S., Hung, M.C. (2009). Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog , 48, 610-617. [CrossRef] [PubMed] [Google Scholar]
  • Xu, Y., Shao, Y., Zhou, J., Voorhees, J.J., Fisher, G.J. (2009). Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytes. J Cell Biochem , 107, 873-880. [CrossRef] [PubMed] [Google Scholar]
  • Zwang, Y., Yarden, Y. (2009). Systems biology of growth factor-induced receptor endocytosis. Traffic, 10, 349-363. [CrossRef] [PubMed] [Google Scholar]

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