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Accueil Tous les numéros Volume 213 / Numéro 3-4 (2019) Biologie Aujourd’hui, 213 3-4 (2019) 131-140 References
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Biologie Aujourd’hui
Volume 213, Number 3-4, 2019
Page(s) 131 - 140
DOI https://doi.org/10.1051/jbio/2019023
Published online 12 décembre 2019
  • Abdel-Hafiz, L., Chao, O.Y., Huston, J.P., Nikolaus, S., Spieler, R.E., de Souza Silva, M.A., Mattern, C. (2016). Promnestic effects of intranasally applied pregnenolone in rats. Neurobiol Learn Mem, 133, 185-195. [CrossRef] [PubMed] [Google Scholar]
  • Akwa, Y., Purdy, R.H., Koob, G.F., Britton, K.T. (1999). The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behav Brain Res, 106, 119-125. [CrossRef] [PubMed] [Google Scholar]
  • Alonso, G., Phan, V., Guillemain, I., Saunier, M., Legrand, A., Anoal, M., Maurice, T. (2000). Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system. Neuroscience, 97, 155-170. [PubMed] [Google Scholar]
  • Barrett-Connor, E., von Muhlen, D., Laughlin, G.A., Kripke, A. (1999). Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: The Rancho Bernardo Study. J Am Geriatr Soc, 47, 685-691. [CrossRef] [PubMed] [Google Scholar]
  • Baulieu, E.E. (1997). Neurosteroids: Of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res, 52, 1-32. [Google Scholar]
  • Baulieu, E.E. (1998). Neurosteroids: A novel function of the brain. Psychoneuroendocrinology, 23, 963-987. [CrossRef] [PubMed] [Google Scholar]
  • Bianchi, M., Baulieu, E.E. (2012). 3beta-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders. Proc Natl Acad Sci USA, 109, 1713-1718. [CrossRef] [Google Scholar]
  • Bianchi, M., Hagan, J.J., Heidbreder, C.A. (2005). Neuronal plasticity, stress and depression: Involvement of the cytoskeletal microtubular system ? Curr Drug Targets CNS Neurol Disord, 4, 597-611. [CrossRef] [PubMed] [Google Scholar]
  • Brown, E.S., Park, J., Marx, C.E., Hynan, L.S., Gardner, C., Davila, D., Nakamura, A., Sunderajan, P., Lo, A., Holmes, T. (2014). A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology, 39, 2867-2873. [CrossRef] [PubMed] [Google Scholar]
  • Busquets-Garcia, A., Soria-Gomez, E., Redon, B., Mackenbach, Y., Vallee, M., Chaouloff, F., Varilh, M., Ferreira, G., Piazza, P.V., Marsicano, G. (2017). Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice. Mol Psychiatry, 22, 1594-1603. [CrossRef] [PubMed] [Google Scholar]
  • Cai, H., Cao, T., Zhou, X., Yao, J.K. (2018). Neurosteroids in schizophrenia: Pathogenic and therapeutic implications. Front Psychiatry, 9, 73. [CrossRef] [PubMed] [Google Scholar]
  • Conde, C., Caceres, A. (2009). Microtubule assembly, organization and dynamics in axons and dendrites. Nat Neurosci, 10, 319-332. [Google Scholar]
  • Corpechot, C., Robel, P., Axelson, M., Sjovall, J., Baulieu, E.E. (1981). Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA, 78, 4704-4707. [CrossRef] [Google Scholar]
  • Corpechot, C., Synguelakis, M., Talha, S., Axelson, M., Sjovall, J., Vihko, R., Baulieu, E.E., Robel, P. (1983). Pregnenolone and its sulfate ester in the rat brain. Brain Res, 270, 119-125. [CrossRef] [PubMed] [Google Scholar]
  • Dastgheib, M., Dehpour, A.R., Heidari, M., Moezi, L. (2015). The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. Neuroscience, 306, 1-9. [PubMed] [Google Scholar]
  • Davis, S.R., Shah, S.M., McKenzie, D.P., Kulkarni, J., Davison, S.L., Bell, R.J. (2008). Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab, 93, 801-808. [CrossRef] [PubMed] [Google Scholar]
  • Debonnel, G., Bergeron, R., de Montigny, C. (1996). Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: An effect mediated via sigma receptors. J Endocrinol, 150 Suppl, S33-42. [CrossRef] [PubMed] [Google Scholar]
  • Dent, E.W., Baas, P.W. (2014). Microtubules in neurons as information carriers. J Neurochem, 129, 235-239. [CrossRef] [PubMed] [Google Scholar]
  • Duman, R.S., Aghajanian, G.K., Sanacora, G., Krystal, J.H. (2016). Synaptic plasticity and depression: New insights from stress and rapid-acting antidepressants. Nat Med, 22, 238-249. [CrossRef] [PubMed] [Google Scholar]
  • Engin, E., Treit, D. (2007). The anxiolytic-like effects of allopregnanolone vary as a function of intracerebral microinfusion site: The amygdala, medial prefrontal cortex, or hippocampus. Behav Pharmacol, 18, 461-470. [CrossRef] [PubMed] [Google Scholar]
  • Flood, J.F., Morley, J.E., Roberts, E. (1992). Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci USA, 89, 1567-1571. [CrossRef] [Google Scholar]
  • Fontaine-Lenoir, V., Chambraud, B., Fellous, A., David, S., Duchossoy, Y., Baulieu, E.E., Robel, P. (2006). Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci USA, 103, 4711-4716. [CrossRef] [Google Scholar]
  • George, M.S., Guidotti, A., Rubinow, D., Pan, B., Mikalauskas, K., Post, R.M. (1994). CSF neuroactive steroids in affective disorders: Pregnenolone, progesterone, and DBI. Biol Psychiatry, 35, 775-780. [CrossRef] [PubMed] [Google Scholar]
  • Harbord, R.P., Wild, W.N. (1956). Observations on steroid anaesthesia; a preliminary report. Proc Royal Soc Med, 49, 487-492. [CrossRef] [Google Scholar]
  • Harrison, N.L., Simmonds, M.A. (1984). Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res, 323, 287-292. [CrossRef] [PubMed] [Google Scholar]
  • Henderson, E., Weinberg, M., Wright, W.A. (1950). Pregnenolone. J Clin Endocrinol Metab, 10, 455-474. [CrossRef] [PubMed] [Google Scholar]
  • Hill, M., Lukac, D., Lapcik, O., Sulcova, J., Hampl, R., Pouzar, V., Starka, L. (1999). Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects. Clin Chem Lab Med, 37, 439-447. [CrossRef] [PubMed] [Google Scholar]
  • Hoogenraad, C.C., Bradke, F. (2009). Control of neuronal polarity and plasticity – A renaissance for microtubules ? Trends Cell Biol, 19, 669-676. [Google Scholar]
  • Hosie, A.M., Wilkins, M.E., da Silva, H.M., Smart, T.G. (2006). Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature, 444, 486-489. [Google Scholar]
  • Kanes, S.J., Colquhoun, H., Doherty, J., Raines, S., Hoffmann, E., Rubinow, D.R., Meltzer-Brody, S. (2017). Open-label, proof-of-concept study of brexanolone in the treatment of severe post-partum depression. Hum Psychopharmacol, 32(2). doi: 10.1002/hup.2576. [Google Scholar]
  • Laurine, E., Lafitte, D., Gregoire, C., Seree, E., Loret, E., Douillard, S., Michel, B., Briand, C., Verdier, J.M. (2003). Specific binding of dehydroepiandrosterone to the N terminus of the microtubule-associated protein MAP2. J Biol Chem, 278, 29979-29986. [CrossRef] [PubMed] [Google Scholar]
  • Lennartsson, A.K., Theorell, T., Kushnir, M.M., Jonsdottir, I.H. (2015). Low levels of dehydroepiandrosterone sulfate in younger burnout patients. PloS one, 10, e0140054. [CrossRef] [PubMed] [Google Scholar]
  • Marx, C.E., Lee, J., Subramaniam, M., Rapisarda, A., Bautista, D.C., Chan, E., Kilts, J.D., Buchanan, R.W., Wai, E.P., Verma, S., Sim, K., Hariram, J., Jacob, R., Keefe, R.S., Chong, S.A. (2014). Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia. Psychopharmacology, 231, 3647-3662. [CrossRef] [PubMed] [Google Scholar]
  • Matsunaga, H., Mizota, K., Uchida, H., Uchida, T., Ueda, H. (2010). Endocrine disrupting chemicals bind to a novel receptor, microtubule-associated protein 2, and positively and negatively regulate dendritic outgrowth in hippocampal neurons. J Neurochem, 114, 1333-1343. [PubMed] [Google Scholar]
  • Maurice, T., Junien, J.L., Privat, A. (1997). Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via sigma 1-receptors. Behav Brain Res, 83, 159-164. [CrossRef] [PubMed] [Google Scholar]
  • Maurice, T., Su, T.P., Privat, A. (1998). Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism. Neuroscience, 83, 413-428. [PubMed] [Google Scholar]
  • Meltzer-Brody, S., Colquhoun, H., Riesenberg, R., Epperson, C.N., Deligiannidis, K.M., Rubinow, D.R., Li, H., Sankoh, A.J., Clemson, C., Schacterle, A., Jonas, J., Kanes, S. (2018). Brexanolone injection in post-partum depression: Two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet, 392, 1058-1070. [CrossRef] [PubMed] [Google Scholar]
  • Meziane, H., Mathis, C., Paul, S.M., Ungerer, A. (1996). The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task. Psychopharmacology, 126, 323-330. [CrossRef] [PubMed] [Google Scholar]
  • Mizota, K., Ueda, H. (2008). N-terminus of MAP2C as a neurosteroid-binding site. Neuroreport, 19, 1529-1533. [CrossRef] [PubMed] [Google Scholar]
  • Monnet, F.P., Maurice, T. (2006). The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: Molecular, physiological, and behavioral aspects. J Pharmacol Sci, 100, 93-118. [CrossRef] [PubMed] [Google Scholar]
  • Morales-Lazaro, S.L., Gonzalez-Ramirez, R., Rosenbaum, T. (2019). Molecular interplay between the Sigma-1 receptor, steroids, and ion channels. Front Pharmacol, 10, 419. [CrossRef] [PubMed] [Google Scholar]
  • Murakami, K., Fellous, A., Baulieu, E.E., Robel, P. (2000). Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly. Proc Natl Acad Sci USA, 97, 3579-3584. [CrossRef] [Google Scholar]
  • Nanfaro, F., Cabrera, R., Bazzocchini, V., Laconi, M., Yunes, R. (2010). Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory. Pharmacol Rep, 62, 265-272. [CrossRef] [PubMed] [Google Scholar]
  • Orentreich, N., Brind, J.L., Rizer, R.L., Vogelman, J.H. (1984). Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab, 59, 551-555. [CrossRef] [PubMed] [Google Scholar]
  • Paresys, L., Hoffmann, K., Froger, N., Bianchi, M., Villey, I., Baulieu, E.E., Fuchs, E. (2016). Effects of the synthetic neurosteroid: 3beta-methoxypregnenolone (MAP4343) on behavioral and physiological alterations provoked by chronic psychosocial stress in tree shrews. Int J Neuropsychopharmacol, 19, 1-12. [Google Scholar]
  • Peixoto, C., Devicari Cheda, J.N., Nardi, A.E., Veras, A.B., Cardoso, A. (2014). The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: A systematic review. Curr Drug Targets, 15, 901-914. [CrossRef] [PubMed] [Google Scholar]
  • Pinna, G., Rasmusson, A.M. (2014). Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder. Front Cell Neurosci, 8, 256. [Google Scholar]
  • Rasmusson, A.M., Pinna, G., Paliwal, P., Weisman, D., Gottschalk, C., Charney, D., Krystal, J., Guidotti, A. (2006). Decreased cerebrospinal fluid allopregnanolone levels in women with post-traumatic stress disorder. Biol Psychiatry, 60, 704-713. [CrossRef] [PubMed] [Google Scholar]
  • Rasmusson, A.M., Marx, C.E., Jain, S., Farfel, G.M., Tsai, J., Sun, X., Geracioti, T.D., Hamner, M.B., Lohr, J., Rosse, R., Summerall, L., Naylor, J.C., Cusin, C., Lang, A.J., Raman, R., Stein, M.B. (2017). A randomized controlled trial of ganaxolone in post-traumatic stress disorder. Psychopharmacology, 234, 2245-2257. [CrossRef] [PubMed] [Google Scholar]
  • Reddy, D.S., Kulkarni, S.K. (1998). Proconvulsant effects of neurosteroids pregnenolone sulfate and dehydroepiandrosterone sulfate in mice. Eur J Pharmacol, 345, 55-59. [CrossRef] [PubMed] [Google Scholar]
  • Ritsner, M.S. (2010). Pregnenolone, dehydroepiandrosterone, and schizophrenia: Alterations and clinical trials. CNS Neurosci Ther, 16, 32-44. [Google Scholar]
  • Ritsner, M., Maayan, R., Gibel, A., Weizman, A. (2007). Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects. Eur Neuropsychopharmacol, 17, 358-365. [CrossRef] [PubMed] [Google Scholar]
  • Romeo, E., Strohle, A., Spalletta, G., di Michele, F., Hermann, B., Holsboer, F., Pasini, A., Rupprecht, R. (1998). Effects of antidepressant treatment on neuroactive steroids in major depression. Am J Psychiatry, 155, 910-913. [CrossRef] [PubMed] [Google Scholar]
  • Sands, D.E., Chamberlain, G.H. (1952). Treatment of inadequate personality in juveniles by dehydroisoandrosterone; preliminary report. Brit Med J, 2, 66-68. [CrossRef] [Google Scholar]
  • Schverer, M., Lanfumey, L., Baulieu, E.E., Froger, N., Villey, I. (2018). Neurosteroids: Non-genomic pathways in neuroplasticity and involvement in neurological diseases. Pharmacol Ther, 191, 190-206. [CrossRef] [PubMed] [Google Scholar]
  • Shirayama, Y., Muneoka, K., Fukumoto, M., Tadokoro, S., Fukami, G., Hashimoto, K., Iyo, M. (2011). Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats. Hippocampus, 21, 1105-1113. [CrossRef] [PubMed] [Google Scholar]
  • Uzunova, V., Sheline, Y., Davis, J.M., Rasmusson, A., Uzunov, D.P., Costa, E., Guidotti, A. (1998). Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci USA, 95, 3239-3244. [CrossRef] [Google Scholar]
  • Vallée, M., Mayo, W., Darnaudery, M., Corpechot, C., Young, J., Koehl, M., Le Moal, M., Baulieu, E.E., Robel, P., Simon, H. (1997). Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus. Proc Natl Acad Sci USA, 94, 14865-14870. [CrossRef] [Google Scholar]
  • Vallée, M., Vitello, S., Bellochio, L., Hébert-Chatelain, E., Monlezun, S., Martin-Garcia, E., Kasanetz, F., Baillie, G.L., Panin, F., Cathala, A., Roullot-Lacarrière, V., Fabre, S., Hurst, D.P., Lynch, D.L., Shore, D.M., Deroche-Gamonet, V., Spampinato, U., Revest, J.M., Maldonado, R., Reggio, P.H., Ross, R.A., Marsicano, G., Piazza, P.V. (2014). Pregnenolone can protect the brain from cannabis intoxication. Science, 343, 94-98. [Google Scholar]
  • Walczak, C.E., Heald, R. (2008). Mechanisms of mitotic spindle assembly and function. Int Rev Cytol, 265, 111-158. [Google Scholar]
  • Weng, J.H., Chung, B.C. (2016). Nongenomic actions of neurosteroid pregnenolone and its metabolites. Steroids, 111, 54-59. [CrossRef] [PubMed] [Google Scholar]
  • Weng, J.H., Liang, M.R., Chen, C.H., Tong, S.K., Huang, T.C., Lee, S.P., Chen, Y.R., Chen, C.T., Chung, B.C. (2013). Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. Nat Chem Biol, 9, 636-642. [Google Scholar]
  • Wieland, S., Lan, N.C., Mirasedeghi, S., Gee, K.W. (1991). Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one. Brain Res, 565, 263-268. [CrossRef] [PubMed] [Google Scholar]
  • Wolkowitz, O.M., Reus, V.I., Roberts, E., Manfredi, F., Chan, T., Raum, W.J., Ormiston, S., Johnson, R., Canick, J., Brizendine, L., Weingartner, H. (1997). Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry, 41, 311-318. [CrossRef] [PubMed] [Google Scholar]
  • Wolkowitz, O.M., Reus, V.I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., Roberts, E. (1999). Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry, 156, 646-649. [PubMed] [Google Scholar]
  • Wong, P., Chang, C.C., Marx, C.E., Caron, M.G., Wetsel W.C., Zhang X. (2012). Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice. PloS one, 7, e51455. [CrossRef] [PubMed] [Google Scholar]

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